40662-76-8

Upstream product

• 154273-28-6 (S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-succinamic acid benzyl ester 
• 154273-29-7 (S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester 

Downstream Products

• 40662-29-1 3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyric acid 
• 40662-12-2 3-(2,5-dihydroxy-3,4,6-trimethylphenyl)-3-methylbutanoic acid 

Relevant academic research and scientific papers

Carbonyl Sulfide (COS) Donor Induced Protein Persulfidation Protects against Oxidative Stress

The emergence of hydrogen sulfide (H2S) as an important signalling molecule in redox biology with therapeutic potential has triggered interest in generating this molecule within cells. One strategy that has been proposed is to use carbonyl sulfide (COS) as a surrogate for hydrogen sulfide. Small molecules that generate COS have been shown to produce hydrogen sulfide in the presence of carbonic anhydrase, a widely prevalent enzyme. However, other studies have indicated that COS may have biological effects which are distinct from H2S. Thus, it would be useful to develop tools to compare (and contrast) effects of COS and H2S. Here we report enzyme-activated COS donors that are capable of inducing protein persulfidation, which is symptomatic of generation of hydrogen sulfide. The COS donors are also capable of mitigating stress induced by elevated reactive oxygen species. Together, our data suggests that the effects of COS parallel that of hydrogen sulfide, laying the foundation for further development of these donors as possible therapeutic agents.

New latent fluorophore for DT diaphorase

This study describes the design and synthesis of a novel latent fluorophore 3 for DT diaphorase based on the trimethyl lock effect and characterization of its enzymatic kinetics. Fluorophore 3 is also a sensitive fluorimetric reagent for detecting glucose when coupled with DTD and glucose dehydrogenase.

Reductive and Bioreductive Activation is Controlled by Electronic Properties of Substituents in Conformationally-Constrained Anticancer Drug Delivery Systems

Conformationally-constrained, anticancer drug delivery systems (TDDS) containing the methyl ester of melphalan (as a model drug) were synthesized using electron-withdrawing or electron-donating functional groups to modulate reductive and bioreductive activation. The electronic nature of substituents in TDDS was found to control reductive and bioreductive activation of TDDS, thus influencing drug delivery from TDDS.

The Redox-Sensitive, Colored N-3-(3',6'-Dioxo-2',4',5'-Trimethylcyclohexa-1',4'-Diene)-3,3-Dimethylpropionyl (Q) Amino-Protecting Group

Amino acids bearing the title (Q) protecting group undergo coupling without racemization via the mixed anhydride technique.Selective deblocking via Na2S2O4.