40665-79-0

Upstream product

• 19810-31-2 Benzyloxyacetyl chloride 
• 756-79-6 dimethyl methane phosphonate 
• 30379-55-6 benzyloxyacetic acid 
• 100-51-6 benzyl alcohol 
• 31600-43-8 methyl 2-(benzyloxy)acetate 
• 100-39-0 benzyl bromide 
• 32122-09-1 ethyl benzyloxyacetate 

Downstream Products

• 129436-67-5 2,2-Dimethyl-propionic acid (E)-(2R,3S)-9-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-1-(2,3-diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-2-methyl-8-oxo-non-6-enyl ester 
• 241155-45-3 (E)-(5R,6S)-1-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-7-trityloxy-hept-3-en-2-one 
• 1580440-21-6 tert-butyl 4-(3-(benzyloxy)-2-oxopropylidene)piperidine-1-carboxylate 
• 141292-95-7 1-((R)-Benzenesulfinylmethyl)-4-benzyloxymethyl-2-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-5-methyl-cyclohex-3-enol 
• 141292-95-7 1-((S)-Benzenesulfinylmethyl)-4-benzyloxymethyl-2-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-5-methyl-cyclohex-3-enol 
• 141293-00-7 (5S,6R,9R)-8-Benzyloxymethyl-6-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one 
• 141293-00-7 (5R,6S,9S)-8-Benzyloxymethyl-6-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one 
• 141393-82-0 [(E)-3-((3R,4S,7S)-6-Benzyloxymethyl-7-methyl-1-oxa-spiro[2.5]oct-5-en-4-yl)-2-methyl-allyloxy]-tert-butyl-dimethyl-silane 
• 141292-93-5 [(E)-3-(6-Benzyloxymethyl-7-methyl-1-oxa-spiro[2.5]oct-5-en-4-yl)-2-methyl-allyloxy]-tert-butyl-dimethyl-silane 
• 141293-02-9 Toluene-4-sulfonic acid (1R,2S,5S)-4-benzyloxymethyl-2-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-1-hydroxy-5-methyl-cyclohex-3-enylmethyl ester 
• 141293-01-8 (2S,5R,6S,9S)-8-Benzyloxymethyl-2-tert-butyl-6-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-9-methyl-1,3-dioxa-spiro[4.5]dec-7-en-4-one 
• 141292-94-6 4-Benzyloxymethyl-2-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-5-methyl-1-phenylsulfanylmethyl-cyclohex-3-enol 
• 141292-99-1 1-Acetoxy-4-benzyloxymethyl-2-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-5-methyl-cyclohex-3-enecarboxylic acid methyl ester 
• 141292-98-0 1-Acetoxy-4-benzyloxymethyl-2-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-5-methyl-cyclohex-3-enecarboxylic acid 

Relevant academic research and scientific papers

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

A general procedure for the preparation of β-ketophosphonates

(Chemical Equation Presented) A mild, high-yielding procedure for the preparation of β-ketophosphonates is described. The condensation is general with respect to the ester and phosphonate, and the products are obtained in high yields within minutes at 0°C. The reaction procedure is operationally simple and amenable to large-scale preparations. 2009 American Chemical Society.

Synthetic study of pinnatoxin A: Intramolecular Diels-Alder approach to the AG-ring

A chiral quaternary carbon (C5) with the G-ring of pinnatoxin A has been diastereoselectively constructed via an intramolecular Diels-Alder reaction.