406676-23-1 Usage
Uses
Used in Pharmaceutical Industry:
2,3,5-Trichloro-4-iodopyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3,5-Trichloro-4-iodopyridine is utilized as a precursor for the production of pesticides and other agrochemicals. Its ability to form stable and effective compounds makes it a valuable component in the development of crop protection products.
Used in Organic Synthesis:
2,3,5-Trichloro-4-iodopyridine is employed as a versatile building block in organic synthesis, enabling the creation of a wide range of complex molecules for various applications. Its high reactivity and compatibility with different chemical reactions contribute to its significance in this field.
Used in Research Laboratories:
Due to its reactivity and potential for forming new compounds, 2,3,5-Trichloro-4-iodopyridine is commonly used in research laboratories for the development and study of novel chemical entities. It serves as a valuable tool for exploring new chemical reactions and understanding the properties of synthesized compounds.
It is crucial to handle 2,3,5-Trichloro-4-iodopyridine with care, as it can pose health and environmental risks if not managed properly. Proper safety measures and disposal methods should be followed to minimize any potential hazards associated with this chemical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 406676-23-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,6,6,7 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 406676-23:
(8*4)+(7*0)+(6*6)+(5*6)+(4*7)+(3*6)+(2*2)+(1*3)=151
151 % 10 = 1
So 406676-23-1 is a valid CAS Registry Number.
InChI:InChI=1/C5HCl3IN/c6-2-1-10-5(8)3(7)4(2)9/h1H
406676-23-1Relevant academic research and scientific papers
Chemoselective Synthesis of Arylpyridines through Suzuki–Miyaura Cross-Coupling Reactions
Perdomo Rivera, Rodisnel,Ehlers, Peter,Ohlendorf, Lars,Torres Rodríguez, Eugenio,Villinger, Alexander,Langer, Peter
, p. 990 - 1003 (2018/03/06)
4-Bromo-2,3,5-trichloro-6-iodopyridine has been synthesized for the first time and applied in chemo- and site-selective Suzuki–Miyaura cross-coupling reactions. This novel starting material allows the selective synthesis of pentaarylpyridines with up to f
Regiochemical flexibility: The optional functionalization of 2,3,5-trihalopyridines at the 4- or 6-position
Bobbio, Carla,Schlosser, Manfred
, p. 4533 - 4536 (2007/10/03)
A deprotonation study was performed using 2,3,5-trichloropyridine, 3,5-dichloro-2-fluoropyridine and 5-chloro-2,3-difluoropyridine as the substrates. Upon reaction with lithium diisopropylamide (LDA), deprotonation occurred exclusively at the 4-position. Subsequent carboxylation and iodination led to the acids 1 and 4-iodopyridines 2. The exposure of the latter compounds to lithium 2,2,6,6-tetramethylpiperidide (LITMP) caused deprotonation and immediately ensuing iodine migration. The intermediates were trapped with dry ice to afford the carboxylic acids 3. Upon neutralization, the 6-iodopyridines 4 were obtained. These compounds readily exchanged the heavy halogen for metal when treated with isopropylmagnesium chloride. In this way, functional groups could be selectively introduced in the 6-position. Employing carbon dioxide routinely as the model electrophile, trihalopyridinecarboxylic acids were formed which, all unknown so far, should provide valuable new building blocks for pharmaceutical research. Moreover, the selective nucleophilic displacement of the halogen at the 2-position could give rise to an immense variety of new structures.
