406923-64-6

Basic information

• Product Name: Isoquinoline, 5-fluoro-1,2,3,4-tetrahydro- (9CI)
• Synonyms: Isoquinoline, 5-fluoro-1,2,3,4-tetrahydro- (9CI);Isoquinoline, 5-fluoro-1,2,3,4-tetrahydro-
• CAS NO: 406923-64-6
• Molecular Formula: C9H10FN
• Molecular Weight: 151.1808032
• Product Categories: HALIDE
• Mol File: 406923-64-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 234.9 °C at 760 mmHg
• Flash Point: 95.9 °C
• Appearance: /
• Density: 1.107 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Isoquinoline, 5-fluoro-1,2,3,4-tetrahydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 5-fluoro-1,2,3,4-tetrahydro- (9CI)(406923-64-6)
• EPA Substance Registry System: Isoquinoline, 5-fluoro-1,2,3,4-tetrahydro- (9CI)(406923-64-6)

Safety Data

• Hazardous Substances Data: 406923-64-6(Hazardous Substances Data)

Usage

General Description

Isoquinoline, 5-fluoro-1,2,3,4-tetrahydro- (9CI) is a chemical compound with the molecular formula C9H9FN. It is a derivative of the heterocyclic compound isoquinoline, which is commonly found in various plant species. This particular compound is a fluorinated version of tetrahydroisoquinoline and is often used in research and drug development due to its potential pharmacological properties. Its structure and properties make it a promising candidate for the development of various pharmaceuticals, especially in the field of neuroscience and mental health. Additionally, its fluorinated structure may also provide unique opportunities for the development of new drug candidates with improved pharmacokinetic and pharmacodynamic profiles.

Upstream product

• 123594-07-0 5-amino-3,4-dihydroisoquinoline-2(H)-carboxylic acid benzyl ester ester 
• 230301-83-4 5-fluoro-3,4-dihydro-2H-isoquinolin-1-one 
• 1438253-33-8 1-bromo-3-fluoro-2-(2-nitroethyl)benzene 
• 52721-69-4 [2-(2-fluorophenyl)ethyl]amine 
• 123594-06-9 5-Nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester 
• 41959-45-9 5-nitro-1,2,3,4-tetrahydroisoquinoline 
• 123594-08-1 N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Intramolecular Reductive Cyclization of o-Nitroarenes via Biradical Recombination

A visible-light-induced/thiourea-mediated intramolecular cyclization of o-nitroarenes under mild conditions is realized for the first time, which provides an efficient and environmentally friendly way to access pharmaceutical relevant quinazolinone derivatives. The reaction can be easily extended to gram level by using a continuous-flow setup with high efficiency. Mechanistic investigation including control experiments, transient fluorescence, UV-vis spectra, and DFT calculations suggests that the formation of active biradical intermediates via intramolecular single electron transfer (SET) is key stage in the catalytic cycle.

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.

NOVEL TETRAHYDROISOQUINOLINES AND TERAHYDRONAPHTHYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula (I): wherein R1, R 2, R 3, U, V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.