230301-83-4

Basic information

• Product Name: 5-FLOUORO-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE
• Synonyms: 5-FLOUORO-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE;1(2H)-Isoquinolinone, 5-fluoro-3,4-dihydro-;5-Fluoro-3,4-dihydroisoquinolin-1(2H)-one;5-Fluoro-3,4-dihydro-1(2H)-isoquinolinone;5-Flouoro-3,4-dihydro-2H-isoquinolin-1-one;5-Fluoro-3,4-dihydroisoquinolin-1(2H)
• CAS NO: 230301-83-4
• Molecular Formula: C₉H₈FNO
• Molecular Weight: 165.06
• Mol File: 230301-83-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 398.8 °C at 760 mmHg
• Flash Point: 195 °C
• Appearance: /
• Density: 1.241 g/cm³
• Storage Temp.: 2-8°C
• PKA: 13.97±0.20(Predicted)
• CAS DataBase Reference: 5-FLOUORO-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLOUORO-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE(230301-83-4)
• EPA Substance Registry System: 5-FLOUORO-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE(230301-83-4)

Safety Data

• Hazardous Substances Data: 230301-83-4(Hazardous Substances Data)

Usage

General Description

5-fluoro-3,4-dihydro-1(2H)-isoquinolinone is a chemical compound with the molecular formula C9H8FNO. It is a fluorinated isoquinolinone derivative that has been studied for its potential pharmacological properties. It is a white solid at room temperature and has a molecular weight of 163.163 g/mol. 5-FLOUORO-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE has been investigated for its potential use as a building block in the synthesis of pharmaceutical compounds and as a potential drug candidate for the treatment of various medical conditions. Its chemical structure and properties make it a promising candidate for further research and development in the field of medicinal chemistry.

Upstream product

• 406923-58-8 2-2-fluorophenylethylcarbamic acid methyl ester 
• 52721-69-4 [2-(2-fluorophenyl)ethyl]amine 
• 699-90-1 3-fluoro-2-methylbenzoic acid 
• 142314-72-5 2-Bromomethyl-3-fluoro-benzoic acid methyl ester 
• 230301-81-2 methyl 3-fluoro-2-methylbenzoate 
• 1438253-33-8 1-bromo-3-fluoro-2-(2-nitroethyl)benzene 
• 201230-82-2 carbon monoxide 
• 230301-82-3 methyl 2-(cyanomethyl)-3-fluorobenzoate 

Downstream Products

• 123594-00-3 5-Fluoro-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Intramolecular Reductive Cyclization of o-Nitroarenes via Biradical Recombination

A visible-light-induced/thiourea-mediated intramolecular cyclization of o-nitroarenes under mild conditions is realized for the first time, which provides an efficient and environmentally friendly way to access pharmaceutical relevant quinazolinone derivatives. The reaction can be easily extended to gram level by using a continuous-flow setup with high efficiency. Mechanistic investigation including control experiments, transient fluorescence, UV-vis spectra, and DFT calculations suggests that the formation of active biradical intermediates via intramolecular single electron transfer (SET) is key stage in the catalytic cycle.

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.

NOVEL TETRAHYDROISOQUINOLINES AND TERAHYDRONAPHTHYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula (I): wherein R1, R 2, R 3, U, V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.