406928-23-2

Basic information

• Product Name: AKOS BBS-00005564
• Synonyms: ASISCHEM C37992;AKOS BBS-00005564;1,3,5-TRIAZINO[1,2-A]BENZIMIDAZOL-2-AMINE, 1,4-DIHYDRO-4-(4-METHYLPHENYL)-;1,4-DIHYDRO-4-(4-METHYLPHENYL)-1,3,5-TRIAZINO[1,2-A]BENZIMIDAZOL-2-AMINE;AKOS VGY0031200;4-(4-methylphenyl)-1,4-dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine
• CAS NO: 406928-23-2
• Molecular Formula: C₁₆H₁₅N₅
• Molecular Weight: 277.32
• Mol File: 406928-23-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AKOS BBS-00005564(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BBS-00005564(406928-23-2)
• EPA Substance Registry System: AKOS BBS-00005564(406928-23-2)

Safety Data

• Hazardous Substances Data: 406928-23-2(Hazardous Substances Data)

Upstream product

• 5418-95-1 2-guanidinobenzimidazole 
• 104-87-0 4-methyl-benzaldehyde 
• 589-18-4 4-Methylbenzyl alcohol 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 1354574-43-8 2-amino-4-(4'-methylphenyl)-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazole hydrochloride 
• 923954-92-1 ethyl 6-(4-methylphenyl)-4-oxo-4,6-dihydro-1^(12)(13)H-pyrimido[2',1':4,5][1,3,5]triazino[1,2-a]benzimidazole-3-carboxylate 

Relevant articles and documents

Ruthenium-catalyzed synthesis of 1,3,5-triazin-2(1: H)-ones and dihydro[1,3,5]triazino[1,2- a] benzimidazoles from alcohols and guanides

An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazinones from alcohols and guanylureas under mild conditions has been developed. The scope of both the alcohols and guanylureas in the reaction is demonstrated. This ruthenium-catalyzed ring-forming process can be successfully extended to 2-guanidinobenzimidazoles to afford substituted dihydro[1,3,5]triazino[1,2-a]benzimidazoles.

Synthesis of novel fused pyrimidines and imidazoles as potential analgesics from 2-amino-4-substituted-striazino[1,2-a]-benzimidazoles

The synthesis of novel fused pyrimidines and imidazole derivatives from 2-amino-s-triazino[1,2-a]benzimidazoles 2a-e and 3a-c was successfully carried out by a ring annelation reaction in a very good yield. Compound 3c was screened for analgesic activity against acetic acid irritation and has shown protection equal to the reference drug (diclofenac sodium). The acute toxicity study revealed that compound 3c is safe up to 300 mg/kg and there is no sign and symptoms of toxicity and mortality for 72 hours.

Synthesis, crystal structure determination and antiproliferative activity of novel 2-amino-4-aryl-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazoles

This manuscript describes the synthesis of novel 2-amino-4-aryl-4,10- dihydro-[1,3,5]triazino[1,2-a]benzimidazoles as hydrochloride salts 4a-n and 5b which were prepared in the reaction of cyclocondensation between 2-guanidinobenzimidazole and versatile h

Synthesis of ethyl 6-aryl-4-oxo-4,6-dihydro-1(12)(13)H-pyrimido-[2′, 1′:4,5][1,3,5]triazino[1,2-a]benzimidazole-3-carboxylates

The synthesis of ethyl 6-aryl-4-oxo-4,6-dihydro-1(12)(13)H- pyrimido[2′,1′:4,5][1,3,5]triazino[1,2-a]-benzimidazole-3- carboxylates (4a-p) was described via pyrimidine ring annulation to 4-aryl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazole-2-amines (2a-p