406950-23-0

Basic information

• Product Name: N-(2-benzoyl-4-nitrophenyl)-2-bromophenylacetic acid amide
• Synonyms: N-(2-benzoyl-4-nitrophenyl)-2-bromophenylacetic acid amide
• CAS NO: 406950-23-0
• Molecular Weight: 439.265
• Mol File: 406950-23-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(2-benzoyl-4-nitrophenyl)-2-bromophenylacetic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-benzoyl-4-nitrophenyl)-2-bromophenylacetic acid amide(406950-23-0)
• EPA Substance Registry System: N-(2-benzoyl-4-nitrophenyl)-2-bromophenylacetic acid amide(406950-23-0)

Safety Data

• Hazardous Substances Data: 406950-23-0(Hazardous Substances Data)

Upstream product

• 18698-97-0 ortho-bromophenylacetic acid 
• 55116-09-1 2-bromophenylacetyl chloride 
• 1775-95-7 2-amino-5-nitrobenzophenone 

Downstream Products

• 406950-24-1 N-(4-amino-2-benzoylphenyl)-2-bromophenylacetic acid amide 

Relevant articles and documents

Non-thiol farnesyltransferase inhibitors: N-(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.

We have designed the nitrophenylfurylacryl-substituted benzophenone 4f as a non-thiol farnesyltransferase inhibitor utilizing a novel aryl binding site of farnesyltransferase. Variation of the 2-acylamino substituent at the benzophenone core structure of

Non-thiol farnesyltransferase inhibitors: N-(4-Acylamino-3-benzoylphenyl)-4-nitrocinnamic acid amides

We have developed a 4-nitrocinnamoyl substituted benzophenone as a novel non-thiol farnesyltransferase inhibitor. Replacement of the p-tolyl moiety of our initial lead structure by different para and ortho substituted phenyl residues as well as by 1-naphthyl resulted in derivatives with considerably enhanced activity displaying IC50 values between 42 and 52 nM. These compounds represent novel, readily accessible non-thiol farnesyltransferase inhibitors being more active than the corresponding thiol-containing analogues. Copyright