406952-80-5

Upstream product

• 50903-99-6 L-NAME 
• 18942-49-9 Boc-D-Phe-OH 

Downstream Products

• 298711-50-9 Boc-DPhe-Arg(NO₂)OH 
• 298711-50-9 2-(S)-(2-(R)-tert-butoxycarbonylamino-3-phenyl-propionylamino)-5-nitroguanidino-pentanoic acid 
• 406953-53-5 [1-(S)-[4-nitroguanidino-1-(2-naphthalen-1-yl-ethylcarbamoyl)-butylcarbamoyl]-2-(R)-phenyl-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Melanocortin receptor ligands

Disclosed are MC-4 and/or MC-3 receptor ligands, the ligands having a structure according to Formula (I): wherein R2, R4, R4′, R5, R6, R6′, R7, R8, R8′, R9, R9′, R10, Ar, Z1, Z2, Z3, X, B, D, p, q, r and s are as described in the specification and claims, and optical isomers, diastereomers or enantiomers thereof; pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides or imides thereof. Also disclosed are pharmaceutical compositions comprising the ligands of Formula (I), as well as methods of treating diseases mediate by the MC-4/MC-3 receptors, as described in the Detailed Descriptions section of the specification.

Selective inhibition of neuronal nitric oxide synthase by N(ω)- nitroarginine- and phenylalanine-containing dipeptides and dipeptide esters

A series of N(ω)-nitroarginine (Arg(NO2))- and phenylalanine- containing dipeptides and dipeptide esters were synthesized as potential selective inhibitors of neuronal nitric oxide synthase (nNOS). All of the dipeptides and dipeptide esters are