50903-99-6

Usage

Definition

ChEBI: An alpha-amino acid ester that is the methyl ester of Ngamma-nitro-L-arginine.

InChI:InChI=1/C7H15N5O4/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15/h5H,2-4,8H2,1H3,(H3,9,10,11)/t5-/m0/s1

Upstream product

• 67-56-1 methanol 
• 2149-70-4 N-nitro-L-arginine 
• 112208-06-7 N^α-(tert-butoxycarbonyl)-N^G-nitro-L-arginine methyl ester 
• 2188-18-3 Boc-Arg(NO₂)-OH 
• 1119-34-2 L-arginine hydrochloride 

Downstream Products

• 106386-19-0 N^α-(N²,N⁶-bis-benzyloxycarbonyl-L-lysyl)-N^ω-nitro-L-arginine methyl ester 
• 66345-00-4 C₁₈H₂₆N₆O₇ 
• 23734-44-3 Cbo-L-Val-nitro-L-Arg-methylester 
• 106655-93-0 -(nitro-L-arginin-methylester) 
• 81666-53-7 Z-glycyl-N^G-nitro-L-arginine methyl ester 
• 26061-11-0 Boc-L-Phe-L-Arg^NO₂-OMe 
• 16876-12-3 N-Benzyloxycarbonyl-(α-tert.butyl-γ-Glu)-(ω-N-nitro-Arg)-methylester 
• 5619-24-9 C₂₃H₃₄N₆O₉ 
• 2785-17-3 N^α-(N²-benzyloxycarbonyl-L-asparaginyl)-N^ω-nitro-L-arginine methyl ester 
• 406952-80-5 2-(S)-(2-(R)-tert-butoxycarbonylamino-3-phenyl-propionylamino)-5-nitroguanidino-pentanoic acid methyl ester 
• 17461-58-4 Boc-L-Phe-L-Arg^NO₂ 
• 135112-38-8 Z-Arg(NO₂)-Pro-Pro-Gly-Phe-5-Ava-Phe-Arg(NO₂)-OMe 
• 135112-29-7 Z-Arg(NO₂)-Pro-5-Ava-Phe-Ser(Ac)-Pro-Phe-Arg(NO₂)-OMe 
• 47556-24-1 H-Phe-Arg(NO₂)-OMe 

Relevant academic research and scientific papers

A class of novel Schiff's bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis

To discover analgesics for treating chronic pain 17 novel Schiff's bases, N,N′-(Z-allylidene-1,3-diyl)bisamino acid methyl esters were prepared from 1,1,3,3,-tetramethoxypropane and amino acid methyl esters. On tail-flick mouse model 20 μmol/kg of these Schiff's bases were orally administered, the analgesic action started 30 min after administration, reached the maximum 120 min after administration, and at 180 min this action was still observed. On a xylene-induced ear edema mouse model 20 μmol/kg of these Schiff's bases exhibited desirable anti-inflammation. Thus the present Schiff's bases are able to treat chronic pain from inflammation. The effect of the side chains of the amino acid residues of these Schiff's bases on the analgesic activity was explained with 3D QSAR.

AZIRIDINE ALDEHYDES, AZIRIDINE-CONJUGATED AMMO DERIVATIVES, AZIRIDINE-CONJUGATED BIOMOLECULES AND PROCESSES FOR THEIR PREPARATION

The present invention relates to unprotected amino aldehydes and applications for same. More particularly, the present invention relates to novel aziridine aldehydes and processes for preparing these novel compounds. The invention also relates to aziridine-conjugated amino derivatives, and processes for preparing the same. Pentacyclic compounds may be prepared using the aziridine aldehydes of the present invention, and the invention relates to these compounds and the processes by which they are made. The invention also relates to aziridine-conjugated bioactive molecules, such as amino acids and peptides, and processes for preparing such compounds.