406954-56-1

Basic information

• Product Name: N^α-(4-nitrophenylacetyl)phenylalanine N-(1,3-dioxolan-2-ylmethyl)-N-methylamide
• Synonyms: N^α-(4-nitrophenylacetyl)phenylalanine N-(1,3-dioxolan-2-ylmethyl)-N-methylamide
• CAS NO: 406954-56-1
• Molecular Weight: 427.457
• Mol File: 406954-56-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N^α-(4-nitrophenylacetyl)phenylalanine N-(1,3-dioxolan-2-ylmethyl)-N-methylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-(4-nitrophenylacetyl)phenylalanine N-(1,3-dioxolan-2-ylmethyl)-N-methylamide(406954-56-1)
• EPA Substance Registry System: N^α-(4-nitrophenylacetyl)phenylalanine N-(1,3-dioxolan-2-ylmethyl)-N-methylamide(406954-56-1)

Safety Data

• Hazardous Substances Data: 406954-56-1(Hazardous Substances Data)

Upstream product

• 57366-77-5 1-(1,3-dioxolan-2-yl)-N-methylmethanamine 
• 1161-13-3 N-Cbz-L-Phe 
• 406954-48-1 cbz-phenylalanine N-(1,3-dioxolan-2-ylmethyl)-N-methylamide 
• 406954-51-6 phenylalanine N-(1,3-dioxolan-2-ylmethyl)-N-methylamide 
• 104-03-0 4-nitrobenzeneacetic acid 

Relevant articles and documents

Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals

Bicyclization of peptide acetals via nucleophilic attack of a phenyl group on an endocyclic acyliminium ion 4 was explored as a route to novel amino acid derived heterocycles and peptidomimetic scaffolds. In the presence of protic acid, bridged structures such as 6 are formed readily from phenylalanine derivatives, but the fused-ring analogues 5 could not be obtained in good yield. In contrast, radical cyclization of the bromophenyl dihydropyrazinone 7 provides an effective alternative for the synthesis of 5 (n = 0, 1, 2). Additional versatility in this process was demonstrated by efficient synthesis of a different fused ring system, represented by the antihelmintic praziquantel, 8.