407-33-0

Basic information

• Product Name: fluoroacetic anhydride
• Synonyms: fluoroacetic anhydride;Bis(fluoroacetic)anhydride;(2-fluoroacetyl) 2-fluoroacetate;2-fluoroacetic acid (2-fluoroacetyl) ester;2-fluoroethanoyl 2-fluoroethanoate;2-fluoroacetic anhydride
• CAS NO: 407-33-0
• Molecular Formula: C₄H₄F₂O₃
• Molecular Weight: 138.0695664
• EINECS: 206-983-4
• Mol File: 407-33-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 129.7°C at 760 mmHg
• Flash Point: 32.2°C
• Appearance: /
• Density: 1.301g/cm³
• Vapor Pressure: 10mmHg at 25°C
• Refractive Index: 1.348
• CAS DataBase Reference: fluoroacetic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: fluoroacetic anhydride(407-33-0)
• EPA Substance Registry System: fluoroacetic anhydride(407-33-0)

Safety Data

• Hazardous Substances Data: 407-33-0(Hazardous Substances Data)

Usage

General Description

Fluoroacetic anhydride is a chemical compound with the formula C2H2F2O3. It is a colorless and pungent-smelling liquid that is highly reactive and can cause severe burns upon contact with skin. fluoroacetic anhydride is often used as a reagent in the synthesis of various organic compounds, particularly in the production of pharmaceuticals and agrochemicals. Due to its highly reactive nature, fluoroacetic anhydride requires careful handling and storage to avoid accidental exposure. It is important to use appropriate safety measures and protective equipment when working with this chemical to prevent potential hazards.

InChI:InChI=1/C4H4F2O3/c5-1-3(7)9-4(8)2-6/h1-2H2

Upstream product

• 144-49-0 Fluoroacetic acid 
• 359-06-8 monofluoroacetyl chloride 

Downstream Products

• 1492-93-9 N,N-Bis-(2-chlor-aethyl)-4-fluoracetamino-anilin 
• 351-05-3 fluoro-acetic acid-(4-bromo-anilide) 
• 485-13-2 fluoroacetyl coenzyme A 
• 38103-12-7 N-{[(E)-4-Chloro-2-methyl-phenylimino]-methyl}-2-fluoro-N-methyl-acetamide 
• 197855-65-5 3-(N-Benzyloxycarbonylphenylalanylamido)-1-fluoro-2-butanone 
• 137362-98-2 <(benzyloxycarbonyl)leucylleucyl-D,L-O-(fluoroacetyl)tyrosyl>fluoromethane 
• 137362-99-3 fluoromethane 
• 664-33-5 2-fluoro-3-hydroxy-2-(α-hydroxy-3-nitro-benzyl)-3-(3-nitro-phenyl)-propionic acid 

Relevant articles and documents

PYRAZOLO-PYRROLIDIN-4-ONE DERIVATIVES AS BET INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASE

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (l) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Efficient and convenient synthesis of symmetrical carboxylic anhydrides from carboxylic acids with sulfated zirconia by phase transfer catalysis

An efficient and convenient procedure for the synthesis of symmetrical carboxylic anhydrides from carboxylic acids with sulfated zirconia by PEG-1000 phase transfer catalysis has been developed. The reactions proceeded under mild and solvent-free conditions to provide the carboxylic anhydrides in good to excellent yields. The product can be isolated by a simple extraction with organic solvent, and the catalyst system can be recycled or reused without any significant loss of catalytic activity.