407-35-2

Basic information

• Product Name: ethyl 3,3-difluoroacrylate
• Synonyms: ethyl 3,3-difluoroacrylate;ethyl 3,3-difluoroprop-2-enoate
• CAS NO: 407-35-2
• Molecular Formula: C₅H₆F₂O₂
• Molecular Weight: 136.0967464
• Mol File: 407-35-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 3,3-difluoroacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3,3-difluoroacrylate(407-35-2)
• EPA Substance Registry System: ethyl 3,3-difluoroacrylate(407-35-2)

Safety Data

• Hazardous Substances Data: 407-35-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 290, 1987 DOI: 10.1021/jo00378a028

Upstream product

• 105836-29-1 ethyl 3-bromo-3,3-difluoropropanoate 
• 352-23-8 ethyl 3,3,3-trifluoropropanoate 
• 1645-58-5 Diethyl 3-bromo-3,3-difluoropropanal diethyl acetal 

Downstream Products

• 108221-68-7 ethyl 2-bromo-3,3,3-trifluoropropanoate 

Relevant articles and documents

Efficient synthetic method of β-fluorocinnamate by arylboronic acids and ethyl 3,3,3-trifluoropropionate under palladium-catalyzed conditions

A convenient and efficient method for synthesizing β-fluorocinnamate and derivatives is reported. Palladium (II) catalysis was employed in β-F elimination and coupling reaction of phenylboronic acid and ethyl 3,3,3-trifluoropropionate with a high yield and E-selectivity. The reaction was conducted under mild conditions and could be widely adapted to boronic acid substrates.

Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection

The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry

Here, we report accessing small 3-fluoropyrrolidines and 3,3-difluoropyrrolidines through a 1,3-dipolar cycloaddition with a simple azomethine ylide and a variety of vinyl fluorides and vinyl difluorides. We demonstrate that vinyl fluorides within α,β-unsaturated, styrenyl and even enol ether systems can participate in the cycloaddition reaction. The vinyl fluorides are relatively easy to synthesize through a variety of methods, making the 3-fluoropyrrolidines very accessible.