40704-45-8Relevant academic research and scientific papers
Manufacture of cefalosporins and intermediates
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Page 8, (2008/06/13)
There is described a process for the preparation of 3-disubstituted cepham-4-carboxylic acid derivatives of formula I wherein R″ is 4-methoxybenzyl, X is the residue of a thioether and Z is a residue of a nucleophilic compound and the conversion of these novel intermediates into the corresponding 3-cephem derivatives by oxidative cleavage of the mercaptan X-SH. By suitable deprotection, these 3-cephem derivatives afford cephalosporins such as ceftiofur, cefotaxime and ceftriaxone.
