48197-94-0

Upstream product

• 101156-43-8 4-methoxybenzyl 7β-phenylacetamido-3-methylenecepham-4-carboxylate 
• 37049-56-2 (6R)-3-methylene-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid; sodium salt 
• 2746-25-0 p-Methoxybenzyl bromide 
• 37795-04-3 (6R)-3-methylene-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid 4-methoxy-benzyl ester 

Downstream Products

• 40704-45-8 (6R)-7t-amino-3-methylene-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid 4-methoxy-benzyl ester; toluene-4-sulfonate 

Relevant academic research and scientific papers

Manufacture of cefalosporins and intermediates

There is described a process for the preparation of 3-disubstituted cepham-4-carboxylic acid derivatives of formula I wherein R″ is 4-methoxybenzyl, X is the residue of a thioether and Z is a residue of a nucleophilic compound and the conversion of these novel intermediates into the corresponding 3-cephem derivatives by oxidative cleavage of the mercaptan X-SH. By suitable deprotection, these 3-cephem derivatives afford cephalosporins such as ceftiofur, cefotaxime and ceftriaxone.