40720-05-6

Usage

Uses

Used in Pharmaceutical Industry:
5-[(1S,2S,5R)-3,3,7-trioxo-3,lambda6-thia-6,8-diazabicyclo[3.3.0]oct-2-yl]pentanoic acid is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique structure and functional groups make it a promising candidate for the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Synthesis:
In the field of organic chemistry, 5-[(1S,2S,5R)-3,3,7-trioxo-3,lambda6-thia-6,8-diazabicyclo[3.3.0]oct-2-yl]pentanoic acid can be utilized as a key building block for the synthesis of more complex molecules. Its diverse functional groups and structural features allow for a wide range of chemical reactions, enabling the creation of novel compounds with potential applications in various industries.
Used in Material Science:
The unique structural features of 5-[(1S,2S,5R)-3,3,7-trioxo-3,lambda6-thia-6,8-diazabicyclo[3.3.0]oct-2-yl]pentanoic acid may also find applications in the development of new materials. Its ability to form stable complexes with other molecules could be harnessed to create advanced materials with specific properties, such as improved mechanical strength, thermal stability, or chemical resistance.
Used in Research and Development:
Due to its complex structure and potential for various applications, 5-[(1S,2S,5R)-3,3,7-trioxo-3,lambda6-thia-6,8-diazabicyclo[3.3.0]oct-2-yl]pentanoic acid can be a valuable compound for research and development purposes. It may serve as a model system for studying the properties and behavior of similar molecules, or as a starting point for the design of new compounds with tailored properties and functions.
Used in Analytical Chemistry:
The unique structural features and functional groups of 5-[(1S,2S,5R)-3,3,7-trioxo-3,lambda6-thia-6,8-diazabicyclo[3.3.0]oct-2-yl]pentanoic acid make it a potential candidate for use in analytical chemistry. It could be employed as a reference compound, a standard for calibration, or a component in the development of new analytical methods or techniques.

InChI:InChI=1/C10H16N2O5S/c13-8(14)4-2-1-3-7-9-6(5-18(7,16)17)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

Upstream product

• 58-85-5 biotin 
• 24608-30-8 5-((3aS)-2,5,5-trioxo-(3ar,6ac)-hexahydro-5λ⁶-thieno[3,4-d]imidazol-4t-yl)-valeric acid methyl ester 
• 608-16-2 biotin methyl ester 

Downstream Products

• 58-85-5 5-((3aS,4R,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid 
• 942121-51-9 1,3-dibenzyl-6-(5-hydroxy-pentyl)-5,5-dioxo-hexahydro-5λ⁶-thieno[3,4-d]imidazol-2-one 
• 942121-50-8 5-(1,3-dibenzyl-2,5,5-trioxo-octahydro-5λ⁶-thieno[3,4-d]imidazol-6-yl)pentanoic acid benzyl ester 

Relevant academic research and scientific papers

The Bioorthogonal Isonitrile-Chlorooxime Ligation

Bioorthogonal reactions are valuable tools for the selective labeling and imaging of natural products and proteins. Here, we present the reaction between isonitriles and chlorooximes as a ligation that proceeds quickly (k ≈ 1 M-1 s-1

Biotin Derivatives

Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.

Isotope and Affinity Tags in Photoreactive Substance P Analogues to Identify the Covalent Linkage within the NK-1 Receptor by MALDI-TOF Analysis

Photoreactive analogues of substance P (biotin sulfone-spacer (amino pentanoic or Gly 3)-Arg-Pro-Lys-Pro-(pBzl)-Phe-Gln-Phe-Phe-Gly-Leu-Met(O 2)NH2) with or without isotope (deuterium) labeling have been synthesized. Deuteriums were present on (d)-biotin or epibiotin sulfone (D3), on the Gly3 spacer linker (D6), or on the Gly in position 9 of SP (D2). Therefore, peptide analogues could be either unlabeled or tri-, penta-, or hexadeuterated. Results obtained with the use of these peptide analogues show that (d)-biotin sulfone and epibiotin sulfone are not recognized with the same affinity by streptavidin, with (d)-biotin sulfone displaying better affinity for the protein. Photolabeling of the human NK-1 receptor with a 1:1 molar ratio of nondeuterated and deuterated photoreactive substance P (SP) analogues in position 5, followed by combined digestions, purification, and MALDI-TOF mass spectrometry analysis, made the identification of the domain of the receptor covalently linked by the photoreactive SP analogue easier. Indeed, doublets in mass spectra were specific for the covalent complex whereas single peaks could be attributed to contaminating species. This method is particularly suitable when minute amounts of complex have to be analyzed, as in the case of highly hydrophobic G-protein coupled receptors.