40722-02-9

Upstream product

• 75-13-8 isocyanic acid 
• 3129-90-6 isothiocyanic acid 
• 28227-38-5 (N,N'-dicyclohexyl)-1,2-ethanediimine 
• 3673-06-1 N,N'-dicyclohexylethylenediimine 
• 131543-46-9 Glyoxal 
• 698-90-8 N'-cyclohexylurea 
• 130473-69-7 (3aR,6aR)-1,4-Dicyclohexyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dithione 

Relevant academic research and scientific papers

A new route to 1,4-disubstituted 5-thioxoperhydroimidazo[4,5-d]imidazol-2-ones

1,4-Disubstituted 5-thioxoperhydroimidazo[4,5-d]imidazol-2-ones were prepared by one-pot criss-cross cycloaddition reactions of 1,4-disubstituted 1,4-diazabuta-1,3-dienes with HNCS and HNCO generated in situ from potassium salts by acetic acid.

Synthesis of new chiral mono-, di-, tri-, and tetraalkylglycolurils

Two general procedures were developed for the synthesis of chiral N-mono-, N, N′-di-, N, N′ N″-tri-, and N, N′, N″, N′″-tetraalkylglycolurils based on the reactions of 4,5-dihydroxy-imidazolidin-2-ones or glyoxal with one or two moles of alkylureas, respectively, by acid catalysis. The reactions of N-monoalkyl- and N, N′-dialkylureas with glyoxal proceed regioselectively. The mechanism of these reactions was suggested and partly confirmed by quantum-chemical calculations and experimental data. The enantiomeric separation of some chiral glycolurils by chiral-phase HPLC was carried out for the first time.

SYNTHESIS OF IMIDAZOIMIDAZOLE-2,5-DITHIONES BY CRISSCROSS ADDITION REACTIONS OF 1,4-DIAZA-1,3-DIENES TO ISOTHIOCYANATOTRIMETHYLSILANE

Treatment of 1,4-disubstituted 1,4-diaza-1,3-dienes with isothiocyanatotrimethylsilane yielded crisscross addition products, 1,4-disubstituted tetrahydroimidazoimidazole-2,5-dithiones.