40734-80-3

Upstream product

• 536-57-2 p-toluene sulfinic acid 
• 100-52-7 benzaldehyde 
• 17356-08-0 thiourea 

Downstream Products

• 199917-20-9 4-hydroxy-4-methyl-6-phenyl-5-ethoxycarbonylhexahydropyrimidine-2-thione 
• 123043-88-9 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione 

Relevant academic research and scientific papers

Different pathways in the reaction of N-(tosylmethyl)-substituted ureas, thioureas, and N′-cyanoguanidines with sodium cyanide. Synthesis of α-ureido nitriles, α-ureido amides, and hydantoin imino derivatives

Reaction of N-(tosylmethyl)-substituted ureas, thioureas, and N′-cyanoguanidines, prepared by condensation of the corresponding amides with various aldehydes and p-toluenesulfinic acid, with NaCN has been studied. The outcome of the reaction is strongly d

Utilization of the amidoalkylation reaction in the synthesis of hydrogenated pyrimidine-2-thiones

Reaction of thiourea, propionic aldehyde, or benzaldehyde and p-toluenesulfinic acid gave α-substituted N-(tosylmethyl)thioureas. Interaction of the last with sodioacetoacetic ester or sodiobenzoylacetic ester led to the synthesis of the corresponding 4-hydroxy-5-ethoxycarbonylhexahydropyrimidine-2-thiones, the dehydration of which afforded 5-ethoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2-thiones. 1997 Plenum Publishing Corporation.