40737-53-9

Basic information

• Product Name: Benzenemethanamine,N-(2-chloroethyl)-N-(1- methylethyl)-
• CAS NO: 40737-53-9
• Molecular Weight: 211.735
• Mol File: 40737-53-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine,N-(2-chloroethyl)-N-(1- methylethyl)- (CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine,N-(2-chloroethyl)-N-(1- methylethyl)- (40737-53-9)
• EPA Substance Registry System: Benzenemethanamine,N-(2-chloroethyl)-N-(1- methylethyl)- (40737-53-9)

Safety Data

• Hazardous Substances Data: 40737-53-9(Hazardous Substances Data)

Upstream product

• 107-20-0 2-chloroethanal 
• 102-97-6 Benzyl-isopropyl-amin 

Downstream Products

• 116078-62-7 (+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanenitrile 

Relevant articles and documents

Synthesis of novel succinamide derivatives having the 5,11-dihydro-6h- pyrido[2,3-b][1,4]benzodiazepin-6-one skeleton as potent and selective M2 muscarinic receptor antagonists. I

A series of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one derivatives containing the succinamide skeleton has been synthesized and evaluated for M1, M2 and M3 muscarinic receptor binding affinities (in vitro) and M2 and M3 muscarinic receptor antagonistic activities (in vivo). Some of them showed higher and more selective binding affinities for M2 muscarinic receptors than that of AF-DX 116. Among them, 11-[3-[N-[2-(N- benzyl-N-methylamino)ethyl]-N-ethylearbamoyl]propionyl]-5,11-dihydro-6H- pyrido[2,3-b][1,4]benzodiazepin-6-one (68) was found to be the most potent and selective M2 muscarinic receptor antagonist in vitro. This compound also strongly inhibited the oxotremorine-induced bradycardia after intravenous administration and showed 130-fold selectivity for M2 muscarinic receptors over M3 muscarinic receptors in vivo.