40739-73-9

Basic information

• Product Name: 2-nitro-7-hydroxybenzofuran
• Synonyms: 2-nitro-7-hydroxybenzofuran;2-Nitrobenzofuran-7-ol
• CAS NO: 40739-73-9
• Molecular Formula: C₈H₅NO₄
• Molecular Weight: 179.13
• Mol File: 40739-73-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 354.3°C at 760 mmHg
• Flash Point: 168.1°C
• Appearance: /
• Density: 1.536g/cm³
• Vapor Pressure: 1.65E-05mmHg at 25°C
• Refractive Index: 1.694
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-nitro-7-hydroxybenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-7-hydroxybenzofuran(40739-73-9)
• EPA Substance Registry System: 2-nitro-7-hydroxybenzofuran(40739-73-9)

Safety Data

• Hazardous Substances Data: 40739-73-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 32, p. 4260, 1984 DOI: 10.1248/cpb.32.4260

InChI:InChI=1/C8H5NO4/c10-6-3-1-2-5-4-7(9(11)12)13-8(5)6/h1-4,10H

Upstream product

• 563-70-2 bromonitromethane 
• 24677-78-9 2,3-dihydroxybenzaldehyde 

Downstream Products

• 96089-25-7 2-nitro-7-benzoyloxybenzofuran 

Relevant articles and documents

Reactions of Salicylaldehydes with Bromonitromethane

Various salicylaldehydes were treated with bromonitromethane in the presence of an inorganic base to give 2-nitrobenzofuran derivatives, and the reaction mechanisms were investigated.The most remarkable feature of the reactions is that 3-hydroxysalicylaldehyde (1k) alone among various hydroxysalicylaldehydes (1b, k, n, r) gave 2-nitro-7-hydroxybenzofuran in good yield.Bromonitromethane reacted with salicylaldehydes at the aldehyde group exclusively to give 1-(2-hydroxyphenyl)-2-bromo-2-nitroethanols (14), followed by cyclization to produce mixtures consisting of cis- and trans-2-nitro-3-hydroxy-2,3-dihydrobenzofurans (8a, b; 9a, b; 10a, b).The stereochemistry of these products is discussed on the basis of the spectral data and chemical reactivities.The intermediates, 2,3-dihydrobenzofurans, underwent dehydration smoothly to give 2-nitrobenzofurans.Keywords - bromonitromethane; salicylaldehyde derivative; ring closure; 2-nitrobenzofuran derivative; cis-2-nitro-3-hydroxy-2,3-dihydrobenzofuran derivative; trans-2-nitro-3-hydroxy-2,3-dihydrobenzofuran derivative; 13C-NMR; stereochemistry; reaction mechanism