40745-44-6

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Acenaphthenamine is utilized as a key intermediate in the synthesis of pharmaceuticals, leveraging its aromatic amine structure to form complex organic compounds with medicinal properties.
Used in Organic Compounds Synthesis:
It serves as a building block in the creation of various organic compounds, contributing to the development of new materials and chemical entities.
Used as a Curing Agent in Epoxy Resins:
1-Acenaphthenamine is employed as a curing agent for epoxy resins, enhancing the cross-linking process and improving the mechanical and thermal properties of the final product.
Used as a Corrosion Inhibitor:
In industrial applications, it functions as a corrosion inhibitor, protecting metal surfaces from degradation and extending the service life of equipment.
Used in Dye Production:
1-Acenaphthenamine is used as an intermediate in the production of dyes, contributing to the coloration and stability of various dye products.
Used in Antioxidant Production:
It also plays a role in the synthesis of antioxidants, which are crucial for preventing oxidative degradation in a range of industrial and consumer products.
It is important to handle 1-Acenaphthenamine with care due to its potential hazards if not used properly, ensuring safety in its applications across different industries.

InChI:InChI=1/C12H11N/c13-11-7-9-5-1-3-8-4-2-6-10(11)12(8)9/h1-6,11H,7,13H2

Upstream product

• 5088-53-9 1(2H)-acenaphthylenone oxime 
• 64-19-7 acetic acid 
• 6306-07-6 1-acenaphthenol 
• 5121-00-6 naphthalen-1-yl-acetyl chloride 
• 86-87-3 naphth-1-yl acetic acid 
• 2235-15-6 1(2H)-acenaphthylenone 

Downstream Products

• 254097-76-2 1-acenaphthen-1-yl-4-phenylamino-piperidine-4-carbonitrile 
• 228246-85-3 (RS)-1-(acenaphthen-1-yl)-4-(p-tolylamino)-piperidine-4-carbonitrile 
• 228246-82-0 (RS)-1-(acenaphthen-1-yl)-4-(m-tolylamino)-piperidine-4-carbonitrile 
• 228246-83-1 (RS)-1-(acenaphthen-1-yl)-4-(3-methoxy-phenylamino)-piperidine-4-carbonitrile 
• 228246-84-2 (RS)-1-(acenaphthen-1-yl)-4-(4-methoxy-phenylamino)-piperidine-4-carbonitrile 
• 254097-82-0 (RS)-4-(4-fluoro-phenylamino)-1-(acenaphthen-1-yl)-piperidine-4-carbonitrile 
• 254097-81-9 (RS)-4-(4-chloro-phenylamino)-1-(acenaphthen-1-yl)-piperidine-4-carbonitrile 
• 228246-81-9 (RS)-1-(acenaphthen-1-yl)-4-(3-chloro-phenylamino)-piperidine-4-carbonitrile 
• 254097-80-8 (RS)-4-(3-fluoro-phenylamino)-1-(acenaphthen-1-yl)-piperidine-4-carbonitrile 
• 247925-20-8 8-Acenaphthen-1-yl-1-(4-fluoro-phenyl)-1,3,8-triaza-spiro[4.5]decan-4-one 

Relevant academic research and scientific papers

REMEDY FOR SLEEP DISTURBANCE

The present invention has been made based on the finding that a compound acting on the ORL-1 receptor as an agonist acts as a non-photic entrainment factor, and advances the circadian rhythm phase, and provides a novel therapeutic agent for a sleep disorder such as circadian rhythm sleep disorder, more particularly, an agent for the prophylaxis and/or treatment of a sleep disorder, which contains an ORL-1 receptor agonist, and a novel compound useful as such agent for the prophylaxis and/or treatment.

8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists

A series of 8-acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4- one derivatives 1 was studied with respect to the binding affinity for the orphanin FQ (OFQ) and opioid (μ, κ, δ) receptors. The influence of stereochemistry as well as the substitution pattern of the phenyl-ring in position 1 on the affinity for the orphanin FQ receptor and selectivity to opioid (μ, κ, δ) receptors is discussed. The most interesting compound 1c was tested for its anxiolytic-like properties in vivo.