40746-60-9

Upstream product

• 5310-17-8 N-(p-tolyl)ethanethioamide 
• 766-97-2 4-n-methylphenylacetylene 
• 54582-23-9 1-p-tolylethanone oxime 
• 122-00-9 para-methylacetophenone 
• 2028-84-4 p-methylbenzenediazonium chloride 
• 103-89-9 4-Methylacetanilide 

Downstream Products

• 726-42-1 di-p-tolylcarbodiimide 
• 47459-89-2 N,N',N''-tris(4-methylphenyl)guanidine 
• 94103-68-1 Methyl-p-tolyl-carbodiimide 
• 94103-52-3 N,N'-Dimethyl-N''-p-tolyl-guanidine 
• 94103-53-4 [1-Methyl-4-[(E)-methylimino]-3-p-tolyl-[1,3]diazetidin-(2Z)-ylidene]-p-tolyl-amine 
• 1792-41-2 2,6-dimethyl-1H-benzo[d]imidazole 
• 64170-57-6 4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)benzoic acid 

Relevant academic research and scientific papers

Stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via a Beckmann rearrangement facilitated by diphenyl phosphorazidate

A novel method for the stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via the Beckmann rearrangement was developed using diphenyl phosphorazidate (DPPA) as both the oxime activator and azide source. Various ketoximes were transformed into the corresponding 1,5-disubstituted tetrazoles with exclusive trans-group migration and no E-Z isomerization of the ketoxime. This method enables the preparation of 1,5-disubstituted tetrazoles without using toxic or explosive azidation reagents.

An efficient synthesis of nitrile, tetrazole and urea from carbonyl compounds

An efficient conversion of carbonyl compounds (aldehydes and ketones) to nitrile, tetrazole, and urea was developed with the use of a POCl3 and sodium azide mixture using a convergent and microwave method. This is the first report on the direct conversion of ketone to urea. The synthesized compounds were characterized by 1H NMR, 13C NMR, mass and IR spectroscopies and were found to be in agreement with reported compounds.

Gold-catalyzed synthesis of tetrazoles from alkynes by Ci￡ C bond cleavage

Golden duality: Tetrazoles are formed by the reaction of alkynes with TMSN3 (TMS=trimethylsilyl) in the presence of iPrOH and the gold(I) catalyst [JohnPhosAu(MeCN)]SbF6. In this transformation gold plays a dual role, first activating the alkyne and then generating a Bronsted acid in situ.

Efficient uncatalyzed conversion of primary and secondary thioamides into 1-substituted, 5-substituted, 1, 5-disubstituted and annulated tetrazoles

Unprecedented high-yield simple and mild conversion of primary aliphatic and aromatic thioamides into 5-substituted tetrazoles on treatment with a combination of tetrachlorosilane and sodium azide in refluxing acetonitrile has been achieved. Secondary acyclic, cyclic, and heterocyclic thioamides could also be transformed in high yields into 1-substituted, 1,5-disubstituted, or annulated tetrazoles under the same reaction condition. Copyright Taylor & Francis Group, LLC.

Efficient synthesis of 1,5-disubstituted tetrazoles

A general method for the synthesis of 1,5-disubstituted tetrazoles from imidoylbenzotriazoles that involves mild reaction conditions and short reaction times. Georg Thieme Verlag Stuttgart.