64170-57-6Relevant academic research and scientific papers
A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group
Obushak, M. D.,Pokhodylo, N. T.,Shyyka, O. Ya.
, p. 802 - 812 (2020/07/03)
Abstract: A convenient method is proposed for constructing the tetrazole ring by a one-pot reaction of amides with phosphorus oxychloride and sodium azide. A series of 1,5-disubstituted tetrazoles containing an amino or a carboxy group, which present interest as buildings blocks for the synthesis of biologically active substances, were obtained.
Kinetics and mechanism of 1-phenyl-5-methyltetrazole nitration in HNO3–H2SO4system
Ostrovskii,Enin,Boiko,Trifonov,Popova,Pavlyukova, Yu. N.,Dolmatov, V. Yu.
, p. 1674 - 1680 (2017/01/28)
At nitration of 1-phenyl-5-methyltetrazole with nitric acid in aqueous solutions of sulfuric acid of 84–96% concentration a mixture forms of 1-(4-nitrophenyl)- and 1-(3-nitrophenyl)-5-methyltetrazoles in a ratio 60: 40. According to kinetic data, the tetrazole ring in the substrate is present in a protonated form. The protonation constants of 1-(4-carboxyphenyl)-5-methyltetrazole at the tetrazole ring and the carboxy group were determined. The Hammet’s electronic constant of the protonated tetrazole ring was calculated.
New compounds, pharmaceutical compositions and uses thereof
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Paragraph 0367; 0368, (2013/03/28)
The present invention relates to compounds of general formula I, wherein the groups R1, LP, LQ, Ar, m and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
N- CYCLOPROPYL - N- PIPERIDINYLBENZAMIDES AS GPR119 MODULATORS
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Page/Page column 88, (2012/10/07)
The present invention relates to compounds of general formula I, wherein the groups R1, LP, LQ, Ar, mand n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
