40749-31-3

Basic information

• Product Name: 2-Benzofuranglyoxylaldehyde
• Synonyms: 2-Benzofuranglyoxylaldehyde;2-(benzofuran-2-yl)-2-oxoacetaldehyde
• CAS NO: 40749-31-3
• Molecular Formula: C₁₀H₆O₃
• Molecular Weight: 174.15284
• Mol File: 40749-31-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 274.1°C at 760 mmHg
• Flash Point: 122.6°C
• Appearance: /
• Density: 1.288g/cm³
• Vapor Pressure: 0.00551mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: 2-Benzofuranglyoxylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzofuranglyoxylaldehyde(40749-31-3)
• EPA Substance Registry System: 2-Benzofuranglyoxylaldehyde(40749-31-3)

Safety Data

• Hazardous Substances Data: 40749-31-3(Hazardous Substances Data)

Usage

General Description

2-Benzofuranglyoxylaldehyde is a chemical compound with the molecular formula C11H6O3. It is a white to yellow solid with a melting point of around 58-60°C. 2-Benzofuranglyoxylaldehyde is commonly used in organic synthesis as a key intermediate for the preparation of various pharmaceuticals, agrochemicals, and fine chemicals. It also has potential applications in the field of materials science, specifically in the development of new functional materials. The chemical properties of 2-Benzofuranglyoxylaldehyde make it a versatile building block for the synthesis of a wide range of complex organic compounds. However, it should be handled with care as it is a potential irritant to the skin, eyes, and respiratory system.

InChI:InChI=1/C10H6O3/c11-6-8(12)10-5-7-3-1-2-4-9(7)13-10/h1-6H

Upstream product

• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 
• 123-91-1 1,4-dioxane 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 95024-88-7 benzofuran-2-yl-glyoxal-bis-phenylhydrazone 
• 496-41-3 Benzofuran-2-carboxylic acid 
• 83123-33-5 N-[2-(4-methylphenyl)-1,1-dimethylethyl]-2-(2-benzofuranyl)-2-hydroxyethanamine 
• 121813-84-1 benzofuran-2-yl-phenyl-ethanedione-bis-phenylhydrazone 

Relevant articles and documents

One-pot three-component reactions of methyl ketones, phenols and a nucleophile: An expedient way to synthesize densely substituted benzofurans

Three-component reactions of phenylglyoxal monohydrate, phenols, and indoles were developed with the aid of acid-catalyst, which produced various densely substituted benzofurans with good to excellent yields. On the basis of this observation, a one-pot, step-wise reaction was developed by using methyl ketones instead of using phenylglyoxal component in I2/DMSO system. At last, three-component reaction offered a useful way to synthesize densely substituted benzofurans starting from simple and easily available substrates. The indole component can be replaced by some other nucleophiles, such as 1,2,4-trimethoxybenzene and thiophenol.

Design and synthesis of 2-acylbenzothiazoles via in situ cross-trapping strategy from benzothiazoles with aryl ketones

An I2/KOH synergistically promoted direct ring-opening aroylation of benzothiazoles with aryl ketones has been discovered. Aryl ketones were seen to act as carbonyl sources to construct 2-acylbenzothiazoles. This reaction could provide an example for the convergent integration of self-labor domino sequences based on an in situ cross-trapping strategy.

Secondary amines and their use in pharmaceutical compositions

Compounds of formula (III): STR1 and esters, amides and pharmaceutically acceptable salts thereof, wherein A1 is hydrogen or methyl; A2 is hydrogen or methyl; n is 1, 2 or 3; and R is hydrogen, chlorine, bromine, hydroxy, nitro, amin