40756-30-7

Upstream product

• 77959-71-8 1-((4,4-dimethyl-2,6-dioxocyclohexylidene)methyl)urea 
• 614-45-9 tert-Butyl peroxybenzoate 
• 3471-13-4 dimedone 
• 29974-49-0 2-(anilinomethylidene)-5,5-dimethylcyclohexane-1,3-dione 

Downstream Products

• 71703-34-9 Acetic acid 2-(1,4,4-trimethyl-2,6-dioxo-cyclohexylmethyl)-benzyl ester 
• 4683-47-0 3-methoxy-2,5,5-trimethyl-cyclohex-2-enone 
• 76999-35-4 2-methyldimedone isobutyl ether 
• 79699-88-0 2,5,5-trimethyl-4,4,6,6-tetrachloro-1,3-cyclohexanedione 
• 91253-70-2 1.1.4-Trimethyl-3-aethyl-cyclohexen-⁽³⁾-on-⁽⁵⁾ 
• 71703-32-7 2-(2-Hydroxymethyl-benzyl)-2,5,5-trimethyl-cyclohexane-1,3-dione 
• 77014-31-4 3-(1,4,4-trimethyl-2,6-dioxocyclohexyl)propanal 

Relevant academic research and scientific papers

Copper-catalyzed methylation of 1,3-diketones with tert-butyl peroxybenzoate

Copper-catalyzed radical methylation of 1,3-diketones with tert-butyl peroxybenzoate in air is described, providing a general pathway to α-methyl 1,3-diketones in moderate to good yields. This protocol has been scaled up to 50?g, and one of the synthesized products can be used in the synthesis of medicine, Rosuvastatin.

A Method for the C-Methylation of Cyclic β-Dicarbonyl Compounds

Cyclic β-dicarbonyl compounds (1, 4, 7, 10) were reacted with either aniline or urea in the presence of trimethoxymethane to give the enamines 2, 5, 8 and 11, resp.The latter were reduced with hydrogen over palladium-charcoal or with the dimethylamine-bor