40756-32-9

Upstream product

• 108010-68-0 3,3-Dimethyl-5-oxo-6-phenyl-hexansaeure 
• 1483-72-3 diphenyliodonium chloride 
• 126-81-8 dimedone 
• 17804-59-0 diethyl 3,3-dimethylglutarate 
• 102158-74-7 4,4-dimethyl-6-phenoxy-4,5-dihydro-[1,1'-biphenyl]-2(3H)-one 
• 591-50-4 iodobenzene 
• 35024-12-5 (4,4-dimethyl-2,6-dioxo-cyclohexyl)-phenyl-iodonium betaine 
• 140-29-4 phenylacetonitrile 
• 100956-28-3 3,3-Dimethyl-5-oxo-6-cyan-6-phenyl-hexansaeure 

Downstream Products

• 1439383-34-2 3'-butyl-4,4-dimethyl-2'-phenylspiro[cyclohexane-1,1'-indene]-2,6-dione 
• 1418302-94-9 6-[(benzenesulfonyl)methyl]-3,3-dimethyl-1H,2H,3H,4H,6Hbenzo[c]chromen-1-one 

Relevant academic research and scientific papers

Palladium-Catalyzed Direct α-Arylation of Indane-1,3-dione to 2-Substituted Indene-1,3-diones

A straightforward and feasible palladium-catalyzed direct α-arylation of indane-1,3-dione to 2-substituted aryl/heteroaryl indene-1,3-diones has been disclosed for the first time. Optimization of reaction conditions identified tBu-XPhos as a preferred ligand for the bis(acetonitrile)dichloropalladium(II) catalyst. A broad spectrum of aryl iodides and aryl triflates containing electron-donating, electron-withdrawing, and sterically hindered substituents gave an excellent yield for the quick access α-arylated 1,3-diones library.

Design, microwave-assisted synthesis, bioactivity and SAR of novel substituted 2-phenyl-2-cyclohexanedione enol ester derivatives

Based on the structure-activity relationship and active substructure combination, a novel class of substituted 2-phenyl-2-cyclohexanedione enol ester derivatives was designed for use as potential herbicide safeners. A microwave-assisted synthetic route was developed for the substituted 2-phenyl-2-cyclohexenone enol ester derivatives via coupling and acylation reactions. In the modified protocol, the reactions were performed under microwave irradiation, resulting in significant improvements in the yields and reaction times. All of the structures were characterized using IR, 1H NMR, 13C NMR and HRMS spectroscopies. The bioassay results demonstrated that most of these compounds could alleviate clethodim injury to maize. Molecular docking modeling showed that the potential antagonism between compound 3(S24) and clethodim plays a key role in the metabolism of herbicides. This paper presents a new safener candidate for maize protection.

Functionalization of Csp3-H and Csp 2-H bonds: Synthesis of spiroindenes by enolate-directed ruthenium-catalyzed oxidative annulation of alkynes with 2-aryl-1,3-dicarbonyl compounds

Ru(de) awakening: The synthesis of carbocycles by the ruthenium-catalyzed oxidative annulation of alkynes with 2-aryl cyclic 1,3-dicarbonyl substrates is described. Proceeding by the functionalization of C sp 3-H and C sp 2-H bonds, and the formation of an all-carbon quaternary center, the reaction provides a diverse range of spiroindenes in good yields with high levels of regioselectivity. Copyright

New highly soluble dimedone-derived iodonium ylides: Preparation, X-ray structure, and reaction with carbodiimide leading to oxazole derivatives

Highly soluble dimedone-derived o-alkoxyphenyliodonium ylides have been prepared and characterized by single crystal X-ray diffraction. These new iodonium ylides are useful reagents for the preparation of oxazole derivatives by reaction with carbodiimides. The Royal Society of Chemistry 2012.