4076-02-2

Basic information

• Product Name: Sodium 2,3-dimercapto-1-propanesulfonate
• Synonyms: 2,3-dimercapto-1-propanesulfonicacimonosodiumsalt;2,3-dimercaptopropanesodiumsulphonate;sodium2,3-dimercaptopropane-1-sulfonate;sodium2,3-dithiolpropanesulfonate;unitiol;2,3-PROPANEDITHIOL-1-SULPHONIC ACID SODIUM SALT;2,3-DIMERCAPTOPROPYLSULPHONIC ACID SODIUM SALT;2,3-DIMERCAPTO-1-PROPANE-SULFONIC ACID SODIUM SALT
• CAS NO: 4076-02-2
• Molecular Formula: C₃H₇O₃S₃*Na
• Molecular Weight: 210.27
• EINECS: 223-796-3
• Product Categories: Sulphur Derivatives;Aliphatics;Organic acids;API
• Mol File: 4076-02-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 215 °C (dec.)
• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: H2O: 0.1 g/mL, clear
• Merck: 14,3210
• BRN: 3734863
• CAS DataBase Reference: Sodium 2,3-dimercapto-1-propanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium 2,3-dimercapto-1-propanesulfonate(4076-02-2)
• EPA Substance Registry System: Sodium 2,3-dimercapto-1-propanesulfonate(4076-02-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• RTECS: TZ6420000
• F: 10-23
• Hazardous Substances Data: 4076-02-2(Hazardous Substances Data)

Usage

Uses

Sodium 2,?3-?Dimercaptopropane-?1-?sulfonate can be used in engineering or chemical process of preparation method of rare earth modified graphene reinforced metal matrix composite bar.

Pharmaceutical Applications

2,3-Dimercapto-1-propanesulfonic acid (DMPS) is also a thiol-containing chelating agent. It also contains sulfhydryl groups and an additional sulfate group. Researchers in the former Soviet Union found that DMPS is a useful chelating agent and has some effect as an antidote to mercury.

InChI:InChI=1/C3H8O3S3.Na/c4-9(5,6)2-3(8)1-7;/h3,7-8H,1-2H2,(H,4,5,6);/q;+1/p-1

Upstream product

• 88031-93-0 2,3-dimercaptopropane-1-sulphonic acid 
• 51116-03-1 sodium 2,3-dibromopropane-1-sulfonate 
• 301-04-2 lead acetate 

Relevant articles and documents

Sodium dimercaptopropansulfonate preparation method

The invention relates to the field of chemical pharmacy, and specifically provides a sodium dimercaptopropansulfonate preparation method. The sodium dimercaptopropansulfonate preparation method comprises that 1) sodium allyl sulfonate and bromine are subjected to a reaction under the effect of an auxiliary agent to obtain sodium dibromo propansulfonate, wherein the auxiliary agent is selected from sodium bromide, sodium iodide, or a combination thereof; 2) the sodium dibromo propanesulfonate obtained in step 1), sodium hydrosulfide and zinc acetate are subjected to a reaction to obtain a sodium dimercaptopropansulfonate-zinc complex; and 3) the sodium dimercaptopropansulfonate-zinc complex obtained in the step 2) reacts with hydrogen sulfide to obtain the sodium dimercaptopropansulfonate. According to the present invention, the preparation method has characteristics of low toxicity of the used reagent, low environmental pollution, low cost of zinc acetate, low consumption, low cost, simple process, no requirement of high pressure equipment and safe operation, and is suitable for industrial production, and the obtained sodium dimercaptopropansulfonate has the high purity and meets the quality requirements of the bulk drug.

An improved synthesis of 2,3-dithiopurine propyl sodium Hydrosulfuryl reaction method

The invention discloses a novel method for sulfhydrylation reaction in a synthesis process of 2,3-sodium dimercaptosulphonate. Different from the existing sulfhydrylation reaction, the sulfhydrylation reaction is fulfilled by introducing high pressure hydrogen sulfide gas into absolute ethyl alcohol solution of sodium alcoholate to obtain sodium hydrosulfide and then adding 2,3-dibromo-1-propanesulfonic acid sodium salt, and carrying out sulfhydrylation reaction under the condition of continuously introducing high pressure hydrogen sulfide in short time and under the high yield. Therefore, the bottleneck technology of the sulfhydrylation reaction in the synthesis process of 2,3-sodium dimercaptosulphonate, which is very troubled, is successfully solved.