407618-18-2Relevant academic research and scientific papers
Aromatic amination/imination approach to chiral benzimidazoles
Rivas, Felix M.,Giessert, Anthony J.,Diver, Steven T.
, p. 1708 - 1711 (2007/10/03)
The powerful Buchwald-Hartwig amination was utilized for the construction of the benzimidazole nucleus with the substituted nitrogen atom bearing a chiral substituent. A successive amination/imination was followed by an acid-catalyzed ring closure step to give the benzimidazole ring. The products were deprotonated and acylated at the C2 position and could be alkylated on nitrogen to give chiral benzimidazolium salts.
