407623-75-0

Upstream product

• 100-44-7 benzyl chloride 
• 5334-40-7 4-nitro-1H-pyrazole-3-carboxylic acid 
• 100-39-0 benzyl bromide 
• 138786-86-4 methyl 4-nitro-1H-pyrazole-3-carboxylate 
• 1024-41-5 benzyl tosylate 

Downstream Products

• 407623-76-1 (1-benzyl-4-nitro-1H-pyrazol-3-yl)methanol 
• 1021498-08-7 methyl 4-amino-1-benzyl-1H-pyrazole-3-carboxylate 
• 1021497-86-8 4-[2-(4-bromo-phenylsulfanyl)-acetylamino]-1-benzyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 1021497-87-9 4-[2-phenylsulfanylacetylamino]-1-benzyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 1021498-09-8 4-(2-bromoacetylamino)-1-benzyl-1H-pyrazole-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

New synthesis of N1- And N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands

The derivatives of the 7-hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide scaffold have been reported recently as potent and selective agonists/inverse agonists of the cannabinoid type-2 receptor (CB2R), but the synthetic way adopted has not yet allowed the structure-activity relationship to be fully explored. Herein, we describe a novel synthetic approach based on the use of a 2-tetrahydropyranyl (THP)-protected precursor that opens the way to obtain either N1- or N2-substituted analogs endowed with agonist or inverse agonist activity, respectively, at the CB2 receptor.

AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME

Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell d

AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC DISEASES CONTAINING THE SAME

The present invention relates to aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduc

Benzodiazepine derivatives

The present invention provides benzodiazepine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of inhibiting activated blood-coagulation factor X. These compounds are usable as agents for treating various diseases concerned with the activated blood-coagulation factor X.