4079-57-6Relevant academic research and scientific papers
Selective Monoacylation of Diols and Asymmetric Desymmetrization of Dialkyl meso-Tartrates Using 2-Pyridyl Esters as Acylating Agents and Metal Carboxylates as Catalysts
Hashimoto, Yuki,Michimuko, Chiaki,Yamaguchi, Koki,Nakajima, Makoto,Sugiura, Masaharu
, p. 9313 - 9321 (2019/08/12)
With 2-pyridyl benzoates as acylating agents and Zn(OAc)2 as a catalyst, 1,2-diols, 1,3-diols, and catechol were selectively monoacylated. Furthermore, the highly enantioselective desymmetrization of meso-tartrates was achieved for the first time, utilizing 2-pyridyl esters and NiBr2/AgOPiv/Ph-BOX in CH3CN or CuCl2/AgOPiv/Ph-BOX in EtOAc catalyst systems (up to 96% ee). The latter catalyst system was also effective for the kinetic resolution of dibenzyl dl-tartrate.
Reductive Cross Coupling Reaction of a Glyoxylate with Carbonyl Compounds. A Facile Synthesis of α,β-Dihydroxycarboxylate Based on a Low Valent Titanium Compound
Mukaiyama, Teruaki,Sugimura, Hideo,Ohno, Takashi,Kobayashi, Shu
, p. 1401 - 1404 (2007/10/02)
On treatment with a low valent titanium compound, a glyoxylate is reductively converted to the titanium enediolate, which reacts with carbonyl compounds to give the corresponding adducts, α,β-dihydroxycarboxylates, in good yields.
