4079-62-3

Usage

Uses

Used in Organic Synthesis:
D,L-Aspartic Acid Dibenzyl Ester-p-Toluenesulfonate is used as a reagent for the formation of peptide bonds and esterification in organic synthesis. Its application is crucial in the synthesis of various organic compounds and pharmaceuticals due to its ability to facilitate the formation of these critical chemical linkages.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, D,L-Aspartic Acid Dibenzyl Ester-p-Toluenesulfonate is used as an intermediate in the synthesis of drugs. Its role in creating peptide bonds and esters is essential for the development of new medications and the modification of existing ones to improve their efficacy and bioavailability.
Used in Research Laboratories:
D,L-Aspartic Acid Dibenzyl Ester-p-Toluenesulfonate is also used in research laboratories for conducting experiments and exploring new chemical reactions. Its stability and reactivity make it a valuable tool for scientists to study the mechanisms of various organic reactions and to develop new synthetic pathways.
Used in Industrial Processes:
In industrial applications, D,L-Aspartic Acid Dibenzyl Ester-p-Toluenesulfonate is employed in the large-scale production of chemicals and pharmaceuticals. Its use in industrial processes helps to ensure the efficient synthesis of target compounds, contributing to the overall productivity and cost-effectiveness of chemical manufacturing.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 617-45-8 aspartic Acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 129472-24-8 dibenzyl N-acetyl-L-tyrosyl-L-aspartate 
• 89099-20-7 N-formylaspartic acid dibenzylester 
• 112160-49-3 2-Benzoyl-2-isocyano-succinic acid dibenzyl ester 
• 112160-48-2 dibenzyl α-benzoyl-α-formylaminosuccinate 
• 89099-05-8 dibenzyl α-isocyanosuccinate 
• 4079-61-2 2-amino-succinic acid dibenzyl ester 

Relevant academic research and scientific papers

A dendron based on natural amino acids: Synthesis and behavior as an organogelator and lyotropic liquid crystal

From linear to dendritic: Glycine is part of the predominant sequence in collagen proteins, and aspartate is similar to the repeating unit of poly(benzyl glutamate)s (PBG)s. Collagen and PBGs are linear peptides that self-organize into fibers and form liq

Enantiomerically Pure Dibenzyl Esters of l -Aspartic and l -Glutamic Acid

(S)-Dibenzyl aspartate p-toluenesulfonate [(S)-1·TsOH] and (S)-dibenzyl glutamate p-toluenesulfonate [(S)-2·TsOH] were efficiently prepared from the respective l-amino acids and benzyl alcohol with very high yields by using cyclohexane as a water azeotroping solvent instead of benzene, carbon tetrachloride, toluene, or benzyl alcohol itself, as reported in literature methods. Preventively, chiral HPLC methods were developed to determine the enantiomeric excess of the two diesters and DSC analyses were performed on the respective p-toluenesulfonates. With the aid of such investigation tools, we demonstrated that (S)-1·TsOH and (S)-2·TsOH were formed enatiomerically pure in cyclohexane, whereas more or less pronounced racemization occurred both in toluene and in benzyl alcohol. The two one-pot procedures, which did not require crystallization of the product or any other purification step, were accomplished on multigram scale.