40796-19-8Relevant academic research and scientific papers
Synthesis of α-Haloalkyl Esters from α-Arylthioalkyl Esters
Benneche, Tore,Strande, Per,Wiggen, Unni
, p. 74 - 77 (2007/10/02)
α-Monohaloalkyl esters have been prepared under mild conditions in high yields by selective cleavage of the carbon-sulfur bond in α-phenylthioalkyl esters using sulfuryl chloride or bromine.The intermediate α-phenylthioalkyl esters have been prepared by alkylation of the corresponding carboxylic acids with readily accessible α-haloalkyl phenyl sulphides.
PREPARATION OF ACYLOXYMETHYL HALIDES FROM ACYLALS
Grynkiewicz, Grzegorz,Tsien, Roger Y.
, p. 443 - 447 (2007/10/02)
Reactions of aliphatic and aromatic acylals with trimethylsilyl bromide under Lewis acid catalysis are discussed.A new, improved procedure for the preparation of bromomethyl acetate (acetoxymethyl bromide) for the preparation of bromomethyl acetate (acetoxymethyl bromide) is described.
Quantitative Evaluation of the Reactivity of Alkylating Agents
Bodor, Nicholas,Kaminski, James J.,Worley, S. D.,Gerson, Steven H.
, p. 758 - 763 (2007/10/02)
A sensitive and reproducible method for quantitative evaluation of the relative reactivities of alkylating agents was developed, based on competitive alkylation.The method is superior to the known calorimetric methods.The reactivities of the agents could also be correlated with the 13C chemical shifts of the α-methylene.The method was successfully applied for the ranking of "soft" alkylating agents of low reactivity. - Keywords: Alkylating Agents, Soft Drugs, NMR Spectra, Competitive Alkylation, Soft Quaternary Salts
Soft drugs. 2. Soft alkylating compounds as potential antitumor agents.
Bodor,Kaminski
, p. 566 - 569 (2007/10/02)
A class of soft alkylating compounds as potential anticancer agents was developed. The first examples include alpha-halo esters of various carboxylic acids. A new method for quantitative evaluation of the alkylating reactivity was developed, using a competitive alkylation reactivity was developed, using a competitive alkylation reaction, followed by NMR analysis of the reaction mixture. The method is sensitive and reproducible. One of the two selected soft alkylating agents, chloromethyl hexanoate, was found to have anticancer activity.
