40808-08-0

Basic information

• Product Name: (2Z)-3-chloro-3-(4-methylphenyl)prop-2-enal
• CAS NO: 40808-08-0
• Molecular Formula: C₁₀H₉ClO
• Molecular Weight: 180.6309
• Mol File: 40808-08-0.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 286.8°C at 760 mmHg
• Flash Point: 142.9°C
• Density: 1.137g/cm³
• Vapor Pressure: 0.00258mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: (2Z)-3-chloro-3-(4-methylphenyl)prop-2-enal(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-3-chloro-3-(4-methylphenyl)prop-2-enal(40808-08-0)
• EPA Substance Registry System: (2Z)-3-chloro-3-(4-methylphenyl)prop-2-enal(40808-08-0)

Safety Data

• Hazardous Substances Data: 40808-08-0(Hazardous Substances Data)

Upstream product

• 18103-98-5 3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one 
• 68-12-2 N,N-dimethyl-formamide 
• 122-00-9 para-methylacetophenone 
• 18103-98-5 (E)-3-(dimethylamino)-1-p-tolylprop-2-en-1-one 

Downstream Products

• 61100-20-7 2-(4-Nitro-phenyl)-5-p-tolyl-thiophene 
• 72806-44-1 1-Chlor-1-p-tolyl-propen-3-al-oxim 
• 1207436-18-7 diisopropyl 3-oxo-5-p-tolyl-1H-pyrazole-1,2(3H)-dicarboxylate 
• 1219452-57-9 (Z)-methyl 5-chloro-3-hydroxy-2-methylene-5-p-tolylpent-4-enoate 
• 1219452-58-0 ethyl (Z)-5-chloro-5-(4-chlorophenyl)-3-hydroxy-2-methylenepent-4-enoate 
• 56377-32-3 (Z)-3-chloro-3-(p-tolyl)acrylic acid 
• 766-97-2 4-n-methylphenylacetylene 
• 1367369-17-2 (S,Z)-4-chloro-1-nitro-4-p-tolylbut-3-en-2-ol 
• 797750-86-8 ethyl (2E,4Z)-5-chloro-5-(p-methylphenyl)-2,4-pentadienoate 
• 51775-50-9 4-(5-p-tolyl-thiophen-2-yl)-benzonitrile 
• 1027940-64-2 ((Z)-3-Oxo-1-p-tolyl-propenylsulfanyl)-phenyl-acetic acid methyl ester 
• 121032-76-6 3-chloro-3-(4-tolyl)prop-2-enol 
• 78583-85-4 (E)-3-Chloro-3-p-tolyl-acrylonitrile 

Relevant articles and documents

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

Unexpected tandem reaction of new type moritabaylis- Hillman adducts promoted by [HMIM]HSO4/NANO3 system

A tandem reaction of new type Baylis-Hillman adducts 1 was prompted by ionic liquid [Hmim]HSO4/NaNO3 system and the unexpected products 6-aryl-2H-pyran-3-carboxylates 2 and imidazolium salts 3 were efficiently formed via the rearrang

Synthesis and biological evaluation of β-chloro vinyl chalcones as inhibitors of TNF-α and IL-6 with antimicrobial activity

A series of β-chloro vinyl chalcones have been synthesized by Claisen-Schmidt condensation. β-chloro vinyl aldehyde has been synthesized by the Vilsmayer-Hack formylation reaction. The structures of the newly synthesized compounds were confirmed by 1H NMR, IR and Mass spectral analysis. All the compounds were evaluated for their anti-inflammatory activity (against TNF-α and IL-6) and antimicrobial (antibacterial and antifungal) activity. Compounds 5a, 5d, 5e, 5g and 5i exhibited promising activity against IL-6 with 58-83% inhibition at 10 μM concentration. None of the compound was found to be cytotoxic in CCK-8 cells at 10 μM concentration. Whereas compounds 5b, 5d, 5e and 5i showed very good antibacterial activity and compounds 5a, 5b, 5e and 5i showed good antifungal activity.