4082-25-1

Basic information

• Product Name: 3-Methyl-5,6-dimethoxy-2,3-dihydro-1H-indene-1-one
• Synonyms: 2,3-Dihydro-5,6-dimethoxy-3-methyl-1H-inden-1-one;3-Methyl-5,6-dimethoxy-2,3-dihydro-1H-indene-1-one;5,6-DiMethoxy-3-Methyl-2,3-dihydro-1H-inden-1-one
• CAS NO: 4082-25-1
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• Mol File: 4082-25-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 90-91 °C
• Boiling Point: 324.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.126±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Methyl-5,6-dimethoxy-2,3-dihydro-1H-indene-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-5,6-dimethoxy-2,3-dihydro-1H-indene-1-one(4082-25-1)
• EPA Substance Registry System: 3-Methyl-5,6-dimethoxy-2,3-dihydro-1H-indene-1-one(4082-25-1)

Safety Data

• Hazardous Substances Data: 4082-25-1(Hazardous Substances Data)

Usage

General Description

3-Methyl-5,6-dimethoxy-2,3-dihydro-1H-indene-1-one is a synthetic chemical compound with the molecular formula C11H14O3. It is a yellow crystalline solid that is commonly used in the production of fragrances and flavors, as well as in the synthesis of other organic compounds. This chemical is known for its sweet and woody odor, which makes it a popular ingredient in the manufacturing of perfumes and scented products. It is also used in the food industry to add a pleasant aroma and flavor to various products. Additionally, it has been studied for its potential pharmaceutical applications, particularly in the field of medicinal chemistry.

Upstream product

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Downstream Products

• 137542-51-9 4-Amino-5-hydroxy-6-methoxy-3-methyl-1-indanone 
• 81323-49-1 C₁₉H₂₂N₂O₄S 

Relevant articles and documents

NEW DERIVATIVES OF 18-CROWN-6 CONTAINING A METHYLINDANONE FRAGMENT IN THE RING

New derivatives of 18-crown-6 containing a methylindanone fragment in the ring have been obtained by the acylation of dibenzo-18-crown-6 with unsaturated acids in the presence of polyphosphoric acid.

Meldrum's acids as acylating agents in the catalytic intramolecular Friedel-Crafts reaction

(Chemical Equation Presented) The intramolecular Friedel-Crafts acylation of aromatics with Meldrum's acid derivatives catalyzed by metal trifluoromethanesulfonates is reported. Meldrum's acids are easily prepared, functionalized, handled, and purified. The synthesis of polysubstituted 1-indanones from benzyl Meldrum's acids was investigated thoroughly, and it was shown that a variety of catalysts were effective, while accommodating a diversity of functional groups under mild conditions. The scope, limitations, and functional group tolerance (terminal alkene and alkyne, ketal, dialkyl ether, dialkyl thioether, aryl methyl ether, aryl TIPS and TBDPS ethers, nitrile- and nitro-substituted aryls, alkyl and aryl halides) for a variety of 5-benzyl (enolizable Meldrum's acids) and 5-benzyl-5-substituted Meldrum's acids (quaternized Meldrum's acids), forming 1-indanones and 2-substituted-1- indanones, respectively, are delineated. This method was further applied to the synthesis of 1-tetralones, 1-benzosuberones, and the potent acetylcholinesterase inhibitor donepezil. Rate of cyclization as a function of ring size was established for various benzocyclic ketones via competition experiments: 1-tetralones form faster than both 1-indanones and 1-benzosuberones, and 1-benzosuberones cyclize faster than 1-indanones.

1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta [ f ] inden -7- ones and 7-substituted benzo [ b ] [ 1,4 ] dioxepin -3-ones

The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions.