90331-19-4Relevant academic research and scientific papers
Synthesis and antitrichinellosis activity of some bis(benzimidazol-2-yl)amines
Mavrova, Anelia Ts.,Denkova, Pavletta,Tsenov, Yordan A.,Anichina, Kameliya K.,Vutchev, Dimitar I.
, p. 6291 - 6297 (2008/04/05)
Novel bis(benzimidazol-2-yl)amines were synthesized using two methods and studied for antitrichinellosis activity. DFT calculations were performed in order to determine the geometry of molecules. All derivatives of 2-aminobenzimidazole exhibited higher activity in vitro against Trichinella spiralis larvae in regard to the activity of albendazole, moreover compounds 4f-i manifested antitrichinellosis effect, which surpassed five times the activity of albendazole. The in vivo screening of intestinal phase of the T. spiralis revealed 100% effectiveness of compounds 4g-i at oral dosages of 50 and 100 mg/kg mw, while albendazole possesses 100% efficacy only at a dose of 100 mg/kg mw.
Synthesis and some conversions of N-substituted benzimidazole-2-sulfonic acids
Divaeva,Kuzmenko,Morkovnik,Komissarov
, p. 463 - 468 (2008/02/02)
A series of N-substituted benzimidazole-2-sulfonic acids was synthesized in good yield by the N-alkylation of benzimidazole-2-sulfonic acids by alkylation with simple and functionalized alkylating agents under mild conditions. The corresponding N-substitu
CONDENSED DERIVATIVES OF BENZAZOLES. 1. SYNTHESIS OF 6- AND 5-SUBSTITUTED BENZIMIDAZOQUINAZOLIN-12-ONES
Popov, I. I.,Boroshko, S. L.,Tertov, B. A.,Makarov, S. P.,Simonov, A. M.,Simkin, B. Ya.
, p. 1348 - 1352 (2007/10/02)
6(5)H-Benzimidazoquinazolin-12-one was obtained in high yield by condensation of benzimidazole-2-sulfonic acid with anthranilic acid.Methods for the introduction of substituents selectively into the 5 and 6 positions of this heterocycle were develo
