408303-43-5 Usage
Description
GW 766994 is an antagonist of chemokine (C-C motif) receptor 3 (CCR3) with a Ki value of 13.8 nM in an assay of eosinophil chemotaxis induced by chemokine (C-C motif) ligand 11 (CCL11). It decreases CCL11-induced cyclin-dependent kinase 5 (Cdk5) and tau phosphorylation and production of amyloid β (1-42) (Aβ42) in isolated mouse hippocampal neurons when used at a concentration of 10 μM.
Check Digit Verification of cas no
The CAS Registry Mumber 408303-43-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,8,3,0 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 408303-43:
(8*4)+(7*0)+(6*8)+(5*3)+(4*0)+(3*3)+(2*4)+(1*3)=115
115 % 10 = 5
So 408303-43-5 is a valid CAS Registry Number.
408303-43-5Relevant articles and documents
Compounds useful in the treatment of inflammatory diseases
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, (2008/06/13)
There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, X a, b, and Z are as defined in the specification, processes for preparing them
