408317-87-3

Upstream product

• 504-01-8 cyclohexane-1,3-diol 
• 75-36-5 acetyl chloride 
• 830-03-5 4-nitrophenol acetate 
• 108-46-3 recorcinol 
• 876-27-7 4-chlorophenyl acetate 

Downstream Products

• 930-68-7 cyclohexenone 
• 1204242-48-7 C₃₃H₃₈ClN₄O₈P 
• 53164-77-5 3-oxocyclohexyl acetate 
• 845508-41-0 3t-tert-Butyl-1-hydroxy-cyclohexan-1r-carbonsaeure 
• 936-99-2 3-tert-butylcyclohexanone 

Relevant academic research and scientific papers

CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR

The present invention relates to a novel molecule with protein tyrosine kinase inhibitory activity, and the synthesis and usage thereof. Specifically, the present invention relates to compound by formula A, pharmaceutically acceptable salts, hydrates or solvates thereof, and the synthesis and usage thereof.

Regio- and stereoselective transacylation of polyhydric alcohols using pronase in organic solvents

Pronase a mixture of proteases from Streptomyces griseus has been found to be a good catalyst for transacylation in organic solvents.With equimolar concentrations of p-nitrophenyl acetate as acyl donor in pyridine, aliphatic diols give predominantly the monoacetates.Glucose and isomeric hexoses give the 6-O-acetates in good yield. 6-Deoxy-sugars however, yield mixtures of acetates indicating that regioselectivity among the secondary hydroxyl groups are poor.Racemic trans-1,2-cyclohexanediol affords the (1R, 2R)-monoacetate in 44percent yield with greater than 90percent enantiomer ic purity. cis-1,2-cyclohexanediol and cis-1,2-cyclohexanedimethanol also give optically active monoacetates.