408328-18-7Relevant articles and documents
Medicine composition for treating fatty liver and preparation method thereof
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Paragraph 0021; 0023; 0024; 0025; 0026, (2018/09/26)
The invention relates to a medical composition for treating a fatty liver. The medical composition is a compound comprising the following structural formula as shown in the description. The inventionfurther relates to a preparation method of the medical composition. The medical composition can reduce TC, TG, AST, ALT, ALP and LDL-C of serum of rats suffering from the fatty liver, and can eliminate accumulation of part of fat in liver cells. The effect of the medical composition on improvement on the fatty liver is similar with acipimox. Compared with a model group, the SOD vitality and the MDA level of dose groups of the medical composition disclosed by the invention is slightly improved. The medical composition has a certain effect of reducing fat and protecting liver, and is hopeful tobe a new medicine clinically.
ANTI-FIBROTIC PYRIDINONES
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Paragraph 0498, (2015/11/02)
This application relates to polycyclic compounds with a pyridinone or pyridinone derivative core including, substituted pyridinones, 5,6- and 6,6- bicyclic heterocycles and substituted pyridine-thiones. This application also discloses methods of preparing these polycyclic compounds, pharmaceutical compositions and medicaments comprising said compounds and methods to treat, prevent or diagnose diseases, disorders or conditions associated with fibrosis.
ANTI-FIBROTIC PYRIDINONES
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Paragraph 0736-0737, (2014/04/17)
Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
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Page/Page column 115; 116; 121; 123; 124, (2011/10/05)
The present invention relates to compounds and methods which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.