96245-97-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2(1H)-Pyridinone, 3-bromo-4-hydroxyis utilized as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique structure allows it to be a key component in the development of new drugs and pesticides, contributing to advancements in healthcare and agriculture.
Used in Corrosion Inhibition:
3-bromo-4-hydroxy-2(1H)-pyridinone has been investigated for its role in corrosion inhibition. Its ability to form protective layers and chelate metal ions makes it a promising candidate for use in industrial applications to prevent corrosion of metals, thereby extending the lifespan of materials and structures.
Used in Material Science:
2(1H)-Pyridinone, 3-bromo-4-hydroxyhas also been studied for its potential as a component in the development of new materials. Its properties, such as the ability to chelate metal ions, suggest that it could be incorporated into the design of advanced materials with specific functionalities, such as sensors or catalysts.
Used in Biological and Pharmacological Research:
2(1H)-Pyridinone, 3-bromo-4-hydroxyhas been explored for its potential biological and pharmacological activities. Its antioxidant properties and metal-chelating capabilities make it an interesting subject for research in the development of new therapeutic agents and understanding its role in biological systems.

InChI:InChI=1/C5H4BrNO2/c6-4-3(8)1-2-7-5(4)9/h1-2H,(H2,7,8,9)

Upstream product

• 626-03-9 3-deazauracil 
• 80791-78-2 3,5-dibromo-2,4-dihydroxypyridine 
• 626-03-9 4-hydroxy-2-pyridone 

Downstream Products

• 80791-79-3 5-bromo-pyridine-2,4-diol 
• 103792-81-0 3-chloro-pyridine-2,4-diol 
• 144584-32-7 3-bromo-2,4-dichloro-pyridine 
• 408328-18-7 5-bromo-2,4-dihydroxy-3-nitropyridine 
• 1415714-30-5 1-benzyl-4-benzyloxy-3-biphenylpyridin-2(1H)-one 
• 1310052-87-9 1-benzyl-4-benzyloxy-3-(4-methoxyphenyl)pyridin-2(1H)-one 
• 1415714-26-9 1-benzyl-4-benzyloxy-3-(4-ethoxyphenyl)pyridin-2(1H)-one 
• 1415714-25-8 1-benzyl-4-benzyloxy-3-(4-trifluoromethoxyphenyl)pyridin-2(1H)-one 
• 1310052-89-1 1-benzyl-4-benzyloxy-3-(3,4-dimethoxyphenyl)pyridin-2(1H)-one 
• 1310052-88-0 1-benzyl-4-benzyloxy-3-(3,4-methylenedioxyphenyl)pyridin-2(1H)-one 
• 1415714-27-0 1-benzyl-4-benzyloxy-3-(4-methylsulfonylphenyl)pyridin-2(1H)-on 
• 571168-92-8 1-benzyl-4-benzyloxy-3-iodopyridin-2(1H)-one 
• 33037-10-4 3-bromo-4-hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone 
• 96246-00-3 3-bromo-2,4-dimethoxypyridine 

Relevant academic research and scientific papers

Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities

A collective synthesis of 4-hydroxy-2-pyridone alkaloids - specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C - has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki-Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μM. Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.

Practical Pd/C-catalysed suzuki-miyaura reactions for the preparation of 3-aryl-4-oxypyridin-2(1H)-ones, 3-aryl-2,4-oxypyridines and 3-aryl-2,4- oxyquinolines as useful intermediates for the synthesis of biologically active compounds

Practical heterogeneous Pd/C-catalysed Suzuki-Miyaura cross-coupling reactions of 3-iodo-4-oxypyridin-2(1H)-ones, 3-iodo-2,4-oxypyridines, and 3-iodo-2,4-oxyquinolines with arylboronic acids are described as a useful and efficient alternative to homogeneous conditions. The methodology features ligand-free and environmentally friendly conditions, and tolerates a wide range of boronic acids. The cross-coupled products can be viewed as useful intermediates for the preparation of 3-aryl-4-hydroxypyridin-2(1H)-ones, which can be used as new nucleobases for antiherpetic agents.

Total synthesis of (±)-cordypyridones A and B and related epimers

"Chemical Equation Presented" Efficient racemic synthesis of two antibacterial and antimalarial natural products, cordypyridones A and B, was achieved from inexpensive, commercially available starting materials In an overall yield of 15% (8% and 7%, respe

A practical 2,3-pyridyne precursor

3-Bromo-2-chloro-4-methoxypyridine has been developed as a practical 2,3-pyridine precursor. The substituted 2,3-pyridine generated from this precursor by halogen-metal exchange has been found to react regioselectively with 2-methoxyfuran and 2-methylfuran.