408335-76-2Relevant academic research and scientific papers
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase
Tang, Jing,Vernekar, Sanjeev Kumar V.,Chen, Yue-Lei,Miller, Lena,Huber, Andrew D.,Myshakina, Nataliya,Sarafianos, Stefan G.,Parniak, Michael A.,Wang, Zhengqiang
, p. 85 - 96 (2017/04/06)
Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H (RNase H) remains the only virally encoded enzymatic function not clinically validated as an antiviral target. 2-Hydroxyisoquinoline-1,3-dione (HID) is known to confer
The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus
Chen, Yue-Lei,Tang, Jing,Kesler, Matthew J.,Sham, Yuk Y.,Vince, Robert,Geraghty, Robert J.,Wang, Zhengqiang
, p. 467 - 479 (2012/02/16)
C7-Substituted 2-hydroxyisoquinoline-1,3-diones inhibit the strand transfer of HIV integrase (IN) and the reverse-transcriptase-associated ribonuclease H (RNH). Hepatitis C virus (HCV) NS5B polymerase shares a similar active site fold to RNH and IN, sugge
