408338-07-8

Upstream product

• 96255-86-6 4-Hydroxy-4',4''-bis(levulinoyloxy)tritanol 
• 123-76-2 levulinic acid 
• 603-45-2 aurin 
• 96255-85-5 4,4',4''-Tris(levulinoyloxy)tritanol 

Downstream Products

• 96255-88-8 S,S-Diphenyl 5'-O-<4,4',4''-tris(levulinoyloxy)trityl>thymidine 3'-phosphorodithioate 
• 96255-87-7 5'-O-<4,4',4''-Tris(levulinoyloxyl)trityl>thymidine 

Relevant academic research and scientific papers

4,4',4''-Tris(levulinoyloxy)trityl as a New Type of Primary Hydroxyl Protecting Group

The 4,4',4''-tris(levulinoxy)trityl (TLTr) group was introduced selectively on the 5'-oxygen of thymidine by use of in situ generated 4,4',4''-tris(levulinoyloxy)trityl bromide.The TLTr group was found to be sufficiently stable to acids and readily removed by hydrazinolysis followed by warming to 50 deg C in pyridine-acetic acid without damage of other protecting groups such as the O-acetyl and 4,4'-dimethoxytrityl groups.The utility of this new protecting group was demonstrated by the successful synthesis of thymidylyl(3'-5')thymidine where the TLTr group was employed as 5'-hydroxyl-protecting group.