408341-58-2Relevant academic research and scientific papers
An efficient synthesis of (2S, 6S)- and meso-diaminopimelic acids via asymmetric hydrogenation
Wang,Xiong,Yang,Hruby
, p. 94 - 98 (2007/10/03)
An efficient synthesis of the title compounds 1 and 2 has been successfully developed. The key step is the asymmetric hydrogenation of dehydroamino acid 7 using [Rh(I)(COD)-(S,S) or - (R,R)-Et-DuPHOS)]+OTf- to produce the optically active, protected amino acid derivatives in high ee (>95%). The approach also can be used for the synthesis of other isomers and analogues.
