408356-75-2

Basic information

• Product Name: 5-methoxy-4-(3-methoxy-phenyl)-isochroman-3-ol
• Synonyms: 5-methoxy-4-(3-methoxy-phenyl)-isochroman-3-ol
• CAS NO: 408356-75-2
• Molecular Weight: 286.328
• Mol File: 408356-75-2.mol

Chemical Properties

• CAS DataBase Reference: 5-methoxy-4-(3-methoxy-phenyl)-isochroman-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-4-(3-methoxy-phenyl)-isochroman-3-ol(408356-75-2)
• EPA Substance Registry System: 5-methoxy-4-(3-methoxy-phenyl)-isochroman-3-ol(408356-75-2)

Safety Data

• Hazardous Substances Data: 408356-75-2(Hazardous Substances Data)

Upstream product

• 408356-66-1 4-methoxy-3-(3-methoxy-phenyl)-3H-isobenzofuran-1-one 
• 591-31-1 3-methoxy-benzaldehyde 
• 6833-23-4 3-methoxy-N-phenylbenzamide 
• 68-12-2 N,N-dimethyl-formamide 
• 408356-68-3 7-methoxy-1-(3-methoxy-phenyl)-1,3-dihydro-isobenzofuran 

Relevant articles and documents

Application of organolithium and related reagents in synthesis. Part 25: Novel specific synthesis of the 4-arylisochroman-3-acetic acids via conversion of benzoic acids

The transformation of the benzanilides 1 into 4-arylisochroman-3-acetic acids 8 applying the following sequence of reactions is described. At first, the 3-arylphthalides 3 were obtained via metallation [n-BuLi] of benzanilides 1 and subsequent treatment of the generated bis-lithiated anilides 2 with aromatic aldehydes. Next, the 3-arylphthalides 3 were reduced [LiBH4] to phthalanes 5 and then, via reductive metallation [Li/C10H8] and reaction of the generated bis-lithiated species 6 with dimethylformamide, 3-hydroxy-4-arylisochromans 7 were produced. In the final step the isochromans 7 were treated with 1-methoxy-1-trimethylsilyloxyethene in the presence of titanium tetrachloride and furnished 4-arylisochromans-3-acetic acid methyl esters 8 as trans stereoisomers (Ψ-e/e).