408523-57-9

Upstream product

• 286-20-4 cyclohexane-1,2-epoxide 
• 20194-18-7 sodium phenyl-methanolate 
• 100-51-6 benzyl alcohol 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 931-17-9 1,2-Cyclohexanediol 
• 64714-16-5 2-Phenyl-hexahydro-benzo[1,3]dioxole 

Downstream Products

• 36713-55-0 (±)-2-benzyloxycyclohexanone 
• 120917-41-1 (R)-4a-Benzyloxy-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one 
• 120917-35-3 (R)-2-Benzyloxy-2-(3-oxo-butyl)-cyclohexanone 
• 120917-33-1 [2-Benzyloxy-cyclohex-(E)-ylidene]-(1-phenyl-ethyl)-amine 
• 120917-37-5 3-((R)-1-Benzyloxy-2-oxo-cyclohexyl)-propionic acid methyl ester 
• 412270-72-5 2-methylenecyclohexyloxymethylbenzene 

Relevant academic research and scientific papers

Zirconium triflate grafted on SBA-15 as a highly efficient solid acid catalyst for ring opening of epoxides by amines and alcohols

Metal (Al, Ti, Zr) triflate grafted mesoporous SBA-15 (AlTf/S, TiTf/S, ZrTf/S) samples were synthesized as inexpensive solid acid materials by a simple one-pot-two-step synthesis methodology. These materials were characterized by X-ray diffraction, N2-sorption, thermogravimetric analysis, Fourier transform infrared spectroscopy (FT-IR), in-situ pyridine FT-IR spectroscopy, and elemental analysis. ZrTf/S was found to be a highly efficient and reusable solid acid catalyst for ring opening of epoxides with amines and alcohols and produced β-amino alcohols and β-alkoxy alcohols respectively under ambient reaction conditions. The ZrTf/S catalyst showed the highest activity, which was attributed to its high acidity compared with that of the Ti and Al containing samples.

Enhanced metal loading in SBA-15-type catalysts facilitated by salt addition: Synthesis, characterization and catalytic epoxide alcoholysis activity of molybdenum incorporated porous silica

We report a novel method to increase the metal loading in SBA-15 silica matrix via direct synthesis. It was demonstrated through the synthesis and characterization of a series of molybdenum containing SBA-15 mesoporous silica catalysts prepared with and without diammonium hydrogen phosphate (DHP) as an additive. Catalysts prepared with DHP show a 2-3 times increase in incorporation of molybdenum in the silica matrix and pore size enlargement. The synthesized catalysts were characterized using nitrogen sorption, X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and inductively coupled plasma-optical emission spectroscopy (ICP-OES). The catalytic activity of catalysts prepared with DHP for alcoholysis of epoxides was superior than the catalyst prepared without DHP. Alcoholysis of epoxides was demonstrated for a range of alcohols and epoxides under ambient conditions in as little as 30 min with high selectivity.

An efficient synthesis of 3-alkyl-1,5,3-dioxazepanes and their use as electrophiles in double-Mannich reactions

An efficient synthesis of 3-alkyl 1,5,3-dioxazepanes was developed for subsequent use in double-Mannich reactions with a variety of carbon-based nucleophiles. It was found that addition of methyltrichlorosilane to the dioxazepane led to a long-lasting rea

Erbium(III) triflate is a highly efficient catalyst for the synthesis of β-alkoxy alcohols, 1,2-diols and β-hydroxy sulfides by ring opening of epoxides

Chemo- and stereoselectivity in the ring-opening reaction of epoxides with erbium(III) triflate are described. Epoxides can be cleaved under neutral conditions with alcohols and thiols in the presence of catalytic amounts of Lewis acid, affording the corresponding β-alkoxy alcohols and β-hydroxy sulfides in high yields. In water, epoxide ring opening occurs to produce the corresponding diols in good yields.

Methylaluminum bis(4-substituted-2,6-di-tert-butylphenoxide) as an efficient nonchelating Lewis acid: Application to asymmetric Diels-Alder reaction and diastereoselective alkylation to alkoxy carbonyl substrates

The exceptionally bulky methylaluminum bis(4-substituted-2,6-di-tert-butylphenoxide) such as MAD or MABR can be successfully utilized as a highly efficient nonchelating Lewis acid for achieving high stereoselectivity in 1,n asymmetric induction in cyclic

ENANTIOSELECTIVE SYNTHESIS OF OXA-SPIRO COMPOUNDS

Optically active compound 10b, efficiently prepared from imine 8b, was transformed into oxa-spiro derivatives 15 and 16.