408539-52-6Relevant articles and documents
Sulfonamide ligands attained through opening of saccharin derivatives
Robinson, Richard I.,Fryatt, Ross,Wilson, Claire,Woodward, Simon
, p. 4483 - 4489 (2006)
Literature N-alkylsaccharins (saccharin-R2) have been shown in some cases to be O-alkylated regioisomers by crystallography (3 structures). The genuine former species react with (S)-H2NCHR1CH 2OH at 101°C in dio
Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors
Gilleron, Pauline,Wlodarczyk, Nicolas,Houssin, Raymond,Farce, Amaury,Laconde, Guillaume,Goossens, Jean-Francois,Lemoine, Amelie,Pommery, Nicole,Henichart, Jean-Pierre,Millet, Regis
, p. 5465 - 5471 (2008/03/11)
A new series of FTase inhibitors containing a tricyclic moiety-dioxodibenzothiazepine or dibenzocycloheptane-has been designed and synthesized. Among them, dioxodibenzothiazepine 18d displayed significant inhibitory FTase activity (IC50 = 17.3