4086-61-7

Upstream product

• 23906-13-0 2-hydrazino-4,6-dimethylpyrimidine 
• 123-54-6 acetylacetone 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 
• 1937-19-5 1-aminoguanidine hydrochloride 
• 2582-30-1 aminoguanidine bicarbonate 

Relevant academic research and scientific papers

Method For Producing Pyrimidinylpyrazole Compounds

The present invention provides a method for producing a pyrimidinylpyrazole compound (1), wherein aminoguanidine (2) or its salt is reacted with a β-diketone compound (3) to produce the pyrimidinylpyrazole compound: wherein R1 and R3 are each independently an alkyl group having 1 to 4 carbon atoms, and R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms. The method is excellent in the environmental compatibility and economic efficiency.

Synthesis and characterization of a few bis- and tris-complexes of iron(II) with 3,5-dimethyl-1-(4′,6′-dimethyl-2′-pyrimidyl)pyrazole [DPymPz

Solid iron(II) complexes [Fe(DPymPz) 2X2].nH2O (X = Cl, Br, SCN, n = 0, 2) and [Fe(DPymPz)3]X2.nH2O (X = ClO4, BF4 and I, n = 0, 2) have been isolated and characterized. The μeff values for bis complexes lie in the range 5.1-5.6 B.M. while this range for the tris complexes is 2.32-2.49 B.M. at 298 K. The diffuse reflectance spectra of all the iron complexes indicate an 5T2g → 5Eg transition. IR data point out the pyrazolyl nitrogen (tertiary) and one of the pyrimidyl nitrogens of DPymPz as bonding sites in forming these complexes and counter ions (X) are coordinated in the bis-species while the same retain their ionic character in the tris complexes. The solid state EPR spectrum of [Fe(DPymPz)2Cl2] at room temperature as well as LNT is recorded to authenticate high-spin FeII state.

Utility of 2-hydrazino-4,6-dimethylpyridine in heterocyclic synthesis

2-Hydrazino-4,6-dimethylpyrimidine (1) readily underwent ring closure with benzoyl chloride to give 5,7-dimethyl-3 phenyl- 1,2,4-triazolo[4,3-a]pyrimidine (4a). Either N-benzoyl derivative (2) or the hydrazone (3a) can be used for formation of compound 4a. Reaction of compound 1 with acetylacetone gave the pyrazole derivative (6) rather than 1,2,4-triazepine derivative (5). The pyrrole (9) was the sole product from cyclization of 1 with 2,5 hexanedione. Reaction of compound 1 with carbon disulphide or ethyl chloroformate gave 1,2,4-triazolo[4,3-a]pyrimidines (10 and 12). The reaction of thiosemicarbazides (13 a-c) with ethyl bromoacetate and DCCD was investigated.