23906-13-0Relevant articles and documents
Synthesis, characterization and in vitro antimicrobial evaluation of some novel hydrazone derivatives bearing pyrimidinyl and pyrazolyl moieties as a promising heterocycles
Kamal, Raj,Kumar, Vipan,Bhardwaj, Vikas,Kumar, Vikas,Aneja, Kamal Rai
, p. 2551 - 2560 (2015)
In the present investigation, ten new 2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)-1-(4,6-dimethylpyrimidin-2-yl)hydrazine (3a-j) having pyrimidinyl and pyrazolyl moieties were synthesized. Structures of all compounds were confirmed by their spectral and elemental data. Most of the tested compounds were found to be significantly more effective against bacterial strains Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa than the reference drug ciprofloxacin. All the newly synthesized compounds were found to be more potent antifungal agents than reference drug against Candida albicans, whereas except 3e all other compounds also shown good activity against Saccharomyces cerevisiae.
Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines
Ostrovskii, Vladimir А.,Danagulyan, Gevorg G.,Nesterova, Olga M.,Pavlyukova, Yulia N.,Tolstyakov, Vladimir V.,Zarubina, Olga S.,Slepukhin, Pavel А.,Esaulkova, Yana L.,Muryleva, Anna А.,Zarubaev, Vladimir V.,Trifonov, Rostislav E.
, p. 448 - 454 (2021/05/21)
[Figure not available: see fulltext.] Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine.
A spectroscopic exploration of the influence of charge donor group on ESIPT process and its consequences in a salicylimine
Makhal, Subhash Chandra,Bhattacharyya, Arghyadeep,Ghosh, Soumen,Guchhait, Nikhil
, p. 138 - 146 (2018/03/21)
Photophysical properties of a newly designed synthetic compound DYMDAP have been investigated in combination with computational calculations. DYMDAP shows a solvent dependent emissive behavior which in non-polar solvents shows two distinct peaks along wit