4087-68-7

Usage

General Description

1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-3-phenyl- is a chemical compound with the molecular formula C18H18O3. It is a derivative of 1H-inden-1-one, and it is characterized by the presence of two methoxy and one phenyl functional groups. 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-3-phenyl- is commonly used in organic synthesis and pharmaceutical research. It can be used for the production of various pharmaceuticals and is also studied for its potential medicinal properties. Additionally, it may have applications in the field of material science and as a reagent in chemical reactions. Overall, 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-3-phenyl- is a versatile chemical compound with diverse potential uses.

Upstream product

• 36317-54-1 β-phenyl-β-(3,4-dimethoxyphenyl)propionic acid 
• 91-16-7 1,2-dimethoxybenzene 
• 140-10-3 (E)-3-phenylacrylic acid 
• 5962-06-1 N-formamido-3-phenyl-2-propenamide 
• 4087-66-5 1-(3,4-dimethoxyphenyl)-3-phenylprop-2-en-1-one 
• 4192-77-2 ethyl cinnamate 
• 100-52-7 benzaldehyde 

Downstream Products

• 4082-15-9 5,6-dimethoxy-3-phenyl-1-oxime-indan 
• 101596-81-0 5,6-dimethoxy-3-phenyl-1H-indene 

Relevant academic research and scientific papers

A metal-free method for the facile synthesis of indanonesviathe intramolecular hydroacylation of 2-vinylbenzaldehyde

A facile method for the synthesis of indanones was developed under metal- and additive-free conditions, whereinl-proline served as an efficient and environmentally benign catalyst. Compared with previously synthesized indanones, synthesis by the transition-metal-catalyzed intramolecular hydroacylation of 2-vinylbenzaldehyde provided a more green synthetic pathway to indanone scaffolds with good to excellent yields. More importantly, it could be used to synthsize the anti-AD drug donepezil.

Superacid-promoted dual C-C bond formation by Friedel-Crafts alkylation and acylation of ethyl cinnamates: Synthesis of indanones

A superacid (triflic acid) promoted dual C-C bond formation via intermolecular Friedel-Crafts alkylation (Michael addition type) and intramolecular acylation for the efficient synthesis of 3-substituted indan-1-ones is presented. This method was successful in activating ethyl cinnamates towards dual aromatic electrophilic substitution. Moreover, it enabled us to synthesize novel spirotetracyclic systems. Georg Thieme Verlag Stuttgart · New York.

Dopamine receptor agonists. I. Synthesis and phamacological evaluation of 4-aryl-substituted analogues of 6,7-dihydroxy-2-amino tetralin (6,7-ADTN) and related indane compounds

Derivatives of cis- and trans-4-phenyl-6,7-dihydroxy-2-aminotetraline and trans-1-phenyl-5,6-dihydroxy-2-aminoindane were synthetized as fenoldopam analogues. They showed no affinity for D1 and D2 binding sites in rat striatal membra

α, β-Unsaturated N-Acylureas as Useful Intermediates for the Synthesis of Indanones, Chromanones and Coumarins

α,β-Unsaturated N-acylureas, viz-N-formamido-2-butenamide (I), N-formamido-3-methyl-2-butenamide (II) and N-formamido-3-phenyl-2-propenamide (III) react with aryl alkyl ethers in the presence of PPA to afford the corresponding crotonophenones and chalcones (IV) at lower temperature and 1-indanones (V) at a higher temperature.Reactions of I and II with phenols in the presence of PPA afford the 4-chromanones (VI), while III gives 3,4-dihydro-4-phenylcoumarins (VII) in excellent yields.