40879-42-3

Basic information

• Product Name: 1,2,3-Propanetriol, 1,3-bis(4-methylbenzenesulfonate)
• Synonyms: 1,3-di-O-tosylglycerol;2-hydroxy-1,3-propanediol-ditosylate;1,3-bis(4-methylbenzenesulfonate)propanetriol;glycerol-1,3-ditosylate;glyceryl 1,3-bis(4-toluenosulfonate);glycerol 1,3-ditosylate
• CAS NO: 40879-42-3
• Molecular Formula: C17H20O7S2
• Molecular Weight: 400.474
• Mol File: 40879-42-3.mol

Chemical Properties

• Melting Point: 45-46 °C
• Boiling Point: 607.6±55.0 °C(Predicted)
• Density: 1.364±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1,2,3-Propanetriol, 1,3-bis(4-methylbenzenesulfonate)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3-Propanetriol, 1,3-bis(4-methylbenzenesulfonate)(40879-42-3)
• EPA Substance Registry System: 1,2,3-Propanetriol, 1,3-bis(4-methylbenzenesulfonate)(40879-42-3)

Safety Data

• Hazardous Substances Data: 40879-42-3(Hazardous Substances Data)

Upstream product

• 19945-19-8 2-(benzyloxy)propane-1,3-diyl bis(4-methylbenzenesulfonate) 
• 1795-31-9 tris(trimethylsilyl) phosphite 
• 118712-54-2 glycidyl p-toluenesulfonate 
• 82964-99-6 1,3-bis(p-toluolsulfonyloxy)-2-(4-carboxyethylbenzolsulfonyloxy)-propan 
• 98-59-9 p-toluenesulfonyl chloride 
• 56-81-5 glycerol 

Downstream Products

• 40879-34-3 2-Stearoyl-1,3-ditosyl-glycerol 
• 433-07-8 2-fluoropropane-1,3-diyl bis(4-methylbenzenesulfonate) 
• 857280-01-4 2,2-difluoropropane-1,3-diyl bis(4-methylbenzenesulfonate) 
• 155401-03-9 glycerol-1,3-ditosylate-2-O-acetylate 
• 1236211-66-7 C₂₂H₂₂O₉S 
• 1236211-61-2 1,3-bis[(tolylsulfonyl)oxy]-2-[(trifluoromethyl)sulfonyl]oxypropane 
• 125836-35-3 1,3-dioxolane-2-one-4-N-(p-tolyl)methanamine 
• 82964-99-6 1,3-bis(p-toluolsulfonyloxy)-2-(4-carboxyethylbenzolsulfonyloxy)-propan 

Relevant articles and documents

6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE COMPOUNDS

The present invention is directed to PDE4B inhibitors of Formula I: (I) or a pharmaceutically acceptable salt thereof, wherein the substituents R1, R2, R 3, and R 4are as defined herein. The invention is also di

Practical synthesis of 1-(2-Nitro-1H-imidazol-1-yl)-3-(tosyloxy) propan-2-yl acetate for the radiosynthesis of [18F]-FMISO

Hypoxia is related with many tumors due to a decreased oxygen condition. Novel synthesis for 1-(2-nitro-1H-imidazol-1-yl)-3-(tosyloxy)propan-2-yl acetate for the radiosynthesis of the [18F]-Flouromisonidazole ([18F]-FMISO), a hypoxia imaging marker used in positron emission tomography, from the readily available starting material is described. In this approach, one-pot two-step syntheses were used for the preparation of the [18F]-FMISO precursors that contain acetyl group. The mild reaction conditions and easy treatments are attractive features in this synthesis. This new synthetic route provides alternative choices for the preparation of hypoxia imaging marker.

CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT

Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula (I), o

Polycations. 17. Synthesis and properties of polycationic derivatives of carbohydrates

In our continuing investigation of polycationic salts for purposes of antimicrobial action, ion-channel blocking, and construction of ionic liquids, we have prepared several series of polycationic salts derived from carbohydrate precursors. These salts are currently being investigated for optimal efficacy as antibacterials and antifungals, as well as for other applications. The syntheses of such series of salts are described here along with preliminary antibacterial testing results and a discussion of their properties indicating their potential utility for several purposes.

Novel generation of pH indicators for proton magnetic resonance spectroscopic imaging

We describe the synthesis of 1,ω-di-1H-imidazoles 2 and 3, derived from L-threitol and D-mannitol, respectively, showing suitable magnetic and toxicological properties, as novel extracellular pH indicators for 1H spectroscopic imaging by magnet

The intramolecular β-fluorine...ammonium interaction in 4- and 8-membered rings

The structures of 3-fluoroazetidinium hydrochloride and 3-fluoro-1,5-diazacyclooctane hydrobromide are explored both by X-ray diffraction analysis and DFT calculations, and the conformations of these molecules are shown to be significantly influenced by t

Reaction of tris(trimethylsilyl) phosphite with epoxides and glicydol derivatives

Tris(trimethylsilyl) phosphite deoxygenates styrene epoxide and tritylglycidol.The same phosphite with glicydyl mesylate gave bis(trimethylsilyl) ester of 3-mesyl-2-trimethylsiloxypropylphosphonic acid by attack at the epoxide methylene carbon.The ester was not stable and reacted further intramolecularly.With glicydyl tosylate and glicydyl 3-nitrobenzenesulfonate, howewer, the reaction was more complicated and glyceryl 1,3-bis(arenosulfonate) was one of the products.With these activated glycidols deoxygenation and reduction of the nitro group were also observed.Key words: Tris(trimethylsilyl) phosphite, tritylglycidol, activated glicidols, phosphonates, Arbuzov reaction.

STUDIEN ZUM VORGANG DER WASSERSTOFFUEBERTRAGUNG.61. Chemische Reaktivitaet und Halbstufenpotential Vergleichende Versuche am Beispiel einiger Arylsulfonsaeurederivate

In arylsulfonyl halides, the half-wave potentials of the corresponding chlorides and fluorides differ by more than 1000 mV, the fluoride being more negative; the influence of para-substituents is small for the chlorides, large for the fluorides.In agreement with the half-wave potentials, arylsulfonyl chlorides are considerably more reactive chemically than the corresponding fluorides.The O-selectivity found for P(O)F compounds is not observed in arylsulfonyl fluorides.Studies of competitive ester formation using primary and secondary alcohols and various arylsulfonyl chlorides yielded no clear analogy to the half-wave potentials.The primary alcohol is always sulfonated in preference to the secondary alcohol, whether the hydroxy functions are present in different molecules or the same molecule.In the latter case, the secondary hydroxyl function is then attacked in a further step by a second, different, arylsulfonyl chloride, giving the compounds 4-8.The further electroreduction of these diesters may be carried out in high yields, giving selective fission of one ester linkage only (that with the more positive potential) provided the difference in the half-wave potentials of the different ester linkages is sufficiently large.In the electroreductive fission the monosulfinic acid and the corresponding alcohol are liberated (see table II).In the competition reaction between phenol and 1:1 mixtures of tosyl chloride (A) and p-carboxyethyl-benzenesulfonyl chloride (B), the chloride with the more positive potential (B), E1/2=72 mV reacts quicker by a factor of 2.5.In competitive Finkelstein reactions, the selectivity was 1:11 at a difference in half-wave potentials of 760 mV (table IV).Arylsulfonates with free secondary alcohol functions may be oxidized smoothly and in high yield to the corresponding ketone using Na2Cr2O7 (3), without effecting the sulfonate linkage.The alkali hydrolysis of n-hexyl para-substituted arylsulfonates follows the Hammett relation but shows a lesser selectivity than was observed in the electroreductive fission of the same esters at the required potentials.Tables VI, VII and VIII concentrate on the preparative importance of the potential-controlled electroreductive fission of aliphatic and aromatic arylsulfonates.The corresponding hydroxy compounds are liberated in yields of up to over 90percent: N-alkyl- and N-aryl arylsulfonamides give analogous results. (table IX)