40893-99-0Relevant academic research and scientific papers
Stereoselective desymmetrizations of dinitriles to synthesize lactones
Baber, Tylisha M.,Bain, Schuyler A.,Caleb Lykins, T.,Frost, Joshua A.,Kelley, Amber M.,Michishita, Emiri,Petersen, Kimberly S.,Youngblood, Kala C.
supporting information, (2021/12/17)
Nitriles are important organic functional groups, allowing for installation of nitrogen in organic synthesis. The Pinner reaction transforms nitriles into esters via the imidate group, but in general has previously necessitated harsh acid conditions. This
Haloalkane dehalogenase catalysed desymmetrisation and tandem kinetic resolution for the preparation of chiral haloalcohols
Westerbeek, Alja,Van Leeuwen, Jan G.E.,Szymański, Wiktor,Feringa, Ben L.,Janssen, Dick B.
experimental part, p. 7645 - 7650 (2012/09/21)
Six different bacterial haloalkane dehalogenases were recombinantly produced in Escherichia coli, purified, and used to catalyse the conversion of prochiral short-chain dihaloalkanes and a meso dihaloalkane, yielding enantioenriched haloalcohols. A two-reaction one-enzyme process was established in which the desymmetrisation of a dihaloalkane is followed by kinetic resolution of the chiral haloalcohol that is produced in the first step. In case of 1,3-dibromo-2-methylpropane and 1,3-dibromo-2-phenylpropane, an increase of the enantiomeric excess of the respective haloalcohol was observed in time, leading to ee values of >97%, with analytical yields of 24 and 52%, respectively. The results show that haloalkane dehalogenases can be used for the production of highly enantioenriched haloalcohols and that in some cases product enantiopurity can be improved by allowing a two-step one-enzyme tandem reaction.
Synthetic studies on condensed-azole derivatives. III. Synthesis and anti- asthmatic activities of C-substituted alkyl side chain derivatives of ω- sulfamoylalkylthioimidazo[1,2-b]pyridazines and related compounds
Kuwahara,Kawano,Shimazu,Yamamoto,Ashida,Miyake
, p. 1516 - 1522 (2007/10/03)
A series of novel alkylthioimidazo[1,2-b]pyridazines was synthesized and evaluated for ability to inhibit platelet activating factor (PAF)-induced bronchoconstriction in guinea pigs. Among them, 3-(imidazo[1,2-h]pyridazin- 6-yl)thio-2,2-dimethylpropanesul
