40901-46-0

Basic information

• Product Name: 6-chlorobenzo[a]phenazin-5(7H)-one
• Synonyms: 6-chloro-5,7-dihydrobenzo[a]phenazin-5-one
• CAS NO: 40901-46-0
• Molecular Formula: C₁₆H₉ClN₂O
• Molecular Weight: 280.7085
• Mol File: 40901-46-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 386.6°C at 760 mmHg
• Flash Point: 187.6°C
• Density: 1.46g/cm³
• Vapor Pressure: 3.5E-06mmHg at 25°C
• Refractive Index: 1.741
• CAS DataBase Reference: 6-chlorobenzo[a]phenazin-5(7H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chlorobenzo[a]phenazin-5(7H)-one(40901-46-0)
• EPA Substance Registry System: 6-chlorobenzo[a]phenazin-5(7H)-one(40901-46-0)

Safety Data

• Hazardous Substances Data: 40901-46-0(Hazardous Substances Data)

Usage

Properties

Colored dye, fluorescent stain for cell imaging and microscopy, antimicrobial, antifungal

Potential Applications

Development of new antibiotics, photodynamic therapy for cancer treatment

Further Research

Needed to fully understand therapeutic potential and safety profile

Upstream product

• 18099-99-5 3-chloro-1,2-naphthoquinone 
• 1526-73-4 3-chloro-2-hydroxy-naphthalene-1,4-dione 
• 95-54-5 1,2-diamino-benzene 
• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 

Downstream Products

• 61316-14-1 N-(2-benzo[a]phenazin-5-ylamino-phenyl)-toluene-4-sulfonamide 
• 61316-66-3 N-(2-benzo[a]phenazin-5-ylamino-phenyl)-acetamide 
• 61316-12-9 N-benzo[a]phenazin-5-yl-benzene-1,2-diamine 

Relevant articles and documents

Micelles catalyzed one pot regio- and chemoselective synthesis of benzo[a]phenazines and naphtho[2,3-d]imidazoles 'in H2O'

An efficient, novel, and concise one pot regio- and chemoselective synthesis of benzo[a]phenazines (4) and naphtho[2,3-d]imidazoles (8) has been accomplished in excellent yields by nucleophilic substitution reaction of 2,3-dichloro-1,4-naphthoquinone (1) with o-phenylenediamine (2) and benzamidines (7) respectively 'in H2O' using base and micelles (SDS) as catalyst. Analog reaction of 2,3-dichloro-1,4-naphthoquinone (1) with 2-aminobenzenethiol (9) under identical conditions led to formation of a mixture of benzo[b]phenothiazine (10), benzo[a]phenothiazine (11), and benzo[a]-1,4-benzothiazino-3,2-phenothiazine (12) in 17%, 23%, and 57% yields, respectively.

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 4-SUBSTITUTED 1,2-NAPHTHOQUINONES, 1,2-NAPHTHALENEDIOLS, AND THEIR DERIVATIVES

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